中药熏蒸联合穴位按摩治疗功能性消化不良疗效观察及对血清5-HT、IL-6、SS水平的影响  

Observation on the Curative Effect of Chinese Medicine Fumigation Combined with Point Massage for Functional Dyspepsia and Its Effects on 5-HT,IL-6,and SS Levels in Serum

作　　者：谢海燕 苏芳[1] 项素娟[1] XIE Haiyan;SU Fang;XIANG Sujuan(Department of Gastroenterology of The Third Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou Zhejiang 310005,China)

机构地区：[1]浙江中医药大学附属第三医院消化内科,浙江杭州310005

出　　处：《新中医》2023年第14期186-190,共5页New Chinese Medicine

摘　　要：目的:观察中药熏蒸联合穴位按摩治疗功能性消化不良的临床疗效及对血清5-羟色胺(5-HT)、白细胞介素(IL)-6、生长抑素(SS)水平的影响。方法:选择100例功能性消化不良患者,按照随机数字表法分为观察组与对照组各50例。对照组采用多潘立酮治疗,观察组在对照组基础上加用中药熏蒸联合穴位按摩治疗。2组均持续治疗4周,比较2组临床疗效、胃肠道症状评分、血清学指标[5-羟色胺(5-HT)、白细胞介素-6 (IL-6)、生长抑素(SS)]、复发率和不良反应发生情况。结果:观察组总有效率为96.00%,高于对照组80.00%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组上腹胀痛、餐后早饱、食欲不振、泛酸烧心等症状评分均较治疗前降低(P<0.05),且观察组上述各项评分均低于对照组(P<0.05)。治疗后,2组血清5-HT水平均较治疗前升高,IL-6、SS水平均较治疗前降低(P<0.05);且观察组血清5-HT水平高于对照组,IL-6、SS水平低于对照组(P<0.05)。治疗结束后随访3个月,观察组复发率为2.08%,对照组为10.00%,2组比较,差异无统计学意义(P>0.05)。治疗期间,2组均无发生明显不良反应。结论:中药熏蒸联合穴位按摩治疗功能性消化不良疗效显著,可有效改善胃肠道血清学指标及炎症因子水平,减轻胃肠道症状,且复发率相对较低。Objective:To observe the clinical effect of Chinese medicine fumigation combined with point massage for functional dyspepsia and its effects on the levels of 5-Hydroxytryptophan(5-HT),interleukin(IL)-6,and somatostatin(SS)in serum.Methods:A total of 100 cases of patients with functional dyspepsia were selected and divided into the observation group and the control group according to the random number table method,with 50 cases in each group.The control group was treated with Domperidone,and the observation group was additionally treated with Chinese medicine fumigation and point massage based on the treatment of the control group.Both groups were treated for four weeks.Clinical effects,gastrointestinal symptom scores,the changes in the levels of serological marker indexes including 5-HT,IL-6,and SS,recurrence rates,and the occurrence of adverse responses were compared between the two groups.Results:The total effective rate was 96.00%in the observation group,higher than that of 80.00%in the control group,the difference being significant(P<0.05).After treatment,the symptom scores of upper abdominal distending pain,early postprandial satiety,poor appetite,and acid reflux and heartburn in the two groups were decreased when compared with those before treatment(P<0.05),and the above scores in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of 5-HT in serum in the two groups were increased when compared with those before treatment,and the levels of IL-6 and SS were decreased when compared with those before treatment(P<0.05);the 5-HT level in serum in the observation group was higher than that in the control group,and the levels of IL-6 and SS in the observation group were lower than those in the control group(P<0.05).During the three-month follow-up after treatment,the recurrence rate was 2.08%in the observation group and 10.00%in the control group,with no significant difference being found in the comparison between the two groups(P>0.05).During treatment,no significan

关 键 词：功能性消化不良 中药熏蒸 穴位按摩 5-羟色胺 白细胞介素-6 生长抑素 

分 类 号：R57[医药卫生—消化系统]