肝细胞癌转化治疗后完全缓解状态的研究进展  

Progress of complete response status after conversion therapy for hepatocellular carcinoma

作　　者：卢帅行 王海清[2] LU Shuaihang;WANG Haiqing(School of Medical and Life Sciences,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,P.R.China;Department of Hepato-Biliary-Pancreatic Surgery,Sichuan Clinical Research Center for Cancer,Sichuan Cancer Hospital&Institute,Sichuan Cancer Center,Affiliated Cancer Hospital of University of Electronic Science and Technology of China,Chengdu 610041,P.R.China)

机构地区：[1]成都中医药大学医学与生命科学学院,成都610075 [2]四川省肿瘤临床医学研究中心,四川省肿瘤医院·研究所,四川省癌症防治中心,电子科技大学附属肿瘤医院肝胆胰外科,成都610041

出　　处：《中国普外基础与临床杂志》2023年第9期1138-1145,共8页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的总结当前研究中有关肝细胞癌(hepatocellular carcinoma,HCC)转化治疗获得影像学完全缓解(complete response,CR)的情况,并探讨获得CR患者的进一步治疗思路及效果。方法查阅国内外关于HCC转化治疗后达到CR的相关研究的文献并进行归纳和总结。结果随着局部治疗、系统治疗及此二者联合治疗在HCC转化治疗过程中取得的重大进展,肿瘤CR发生比例越来越高;对于转化治疗后达CR的患者,手术切除、肝移植、予以维持治疗或随访观察等均可作为选择的治疗方式,而且均能显示出生存获益。结论从本综述总结出的观点,随着靶向治疗和免疫治疗研究的进展,以及新型抗肿瘤药物的出现,肝癌转化治疗可供选择的方案越来越多,达CR患者占比也越来越高。目前针对转化治疗成功后获得CR的患者,可选择手术治疗或非手术治疗,但对于选择何种治疗方式可使患者获益更多尚无权威的结论,目前的现状是基于患者的个体情况制定相应的个体化治疗方案,从而使患者生存获益更理想。Objective To summarize the complete response(CR,which referred to the imaging level)achieved by conversion therapy for hepatocellular carcinoma(HCC)in the current researches,and explore the further therapy strategies and outcomes for patients acquired CR.Method The domestic and foreign literature on the research of CR achieved by conversion therapy for HCC was reviewed and summarized.Results With the great progress of conversion therapy such as local therapy,systemic therapy,and local therapy in combination with systemic therapy for HCC,the proportion of the CR was increasing after conversion therapy.For the patients who achieved CR after conversion therapy,the surgical resection,liver transplantation,follow-up observation,etc.could be selected and showed a survival benefit.Conclusions From the opinion summarized in this review,with the development of targeted therapy and immunotherapy,as well as the new anti-tumor drugs,a growing number of conversion therapeutic schedules could be provided,CR rate was increasing.At present,for patients who have achieved CR after conversion therapy,surgical or nonsurgical treatment can be chosen.However,there is no authoritative conclusion on which therapy method can benefit patients more.The current strategy is to perform personalized treatment plan based on the individual situation of patient,in order to achieve better survival benefit for patient.

关 键 词：肝细胞癌 完全缓解 病理学完全缓解 治疗 

分 类 号：R735.7[医药卫生—肿瘤]