脑内酸碱平衡改变对癫痫发生发展的影响  

Effects of acid-base balance in the brain in epileptogenesis

作　　者：卢倩 张淇[1,2] 王杨阳 王秋红[1,2] 敦硕 王嘉[1,2] 邹丽萍 LU Qian;ZHANG Qi;WANG Yangyang;WANG Qiuhong;DUN Shuo;WANG Jia;ZOU Liping(Medical School of Chinese PLA,Beijing 100853,China;Department of Pediatrics,the First Medical Center of PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军医学院,北京100853 [2]解放军总医院第一医学中心儿内科,北京100853

出　　处：《癫痫杂志》2023年第5期400-405,共6页Journal of Epilepsy

基　　金：北京亦城合作发展基金会(YCXJ-JZ-2022-007)。

摘　　要：大脑微环境的酸碱平衡对正常发挥神经系统功能至关重要。维持脑中酸碱平衡稳态的机制十分复杂,由多种转运蛋白和酶共同调节。酸碱平衡的波动对整个大脑的活动产生影响,可以影响神经元的兴奋性,甚至会导致癫痫发作。癫痫是常见的神经系统疾病,其发病机制十分复杂,病因众多,药物治疗仍是主要方法,但是治疗效果有限,因此迫切需阐明癫痫的病理机制,探索新的治疗方向。本文概述了参与大脑酸碱平衡的调节的转运蛋白(酸敏感离子通道、Na^(+)/H^(+)交换体、Na^(+)/HCO_(3)^(−)共转运体、阴离子转换体、碳酸酐酶等)以及肺部对酸碱平衡的调节。从基础和临床两方面详细的介绍了这些转运蛋白如何参与大脑酸碱平衡稳定的维持,以及对癫痫发生发展的影响,为癫痫治疗和干预的提供新靶点。The acid-base balance of the brain is critical to the functioning of the nervous system.The mechanisms that maintain acid-base homeostasis in the brain are complex and regulated by a variety of transporter proteins and enzymes.Slight changes in acid-base balance can affect neuronal excitability and even lead to epilepsy.Epilepsy is a common neurological disease with complex pathogenesis and numerous causes.Drug therapy is still the main method,but the treatment effect is limited.Therefore,it is urgent to clarify the pathological mechanism of epilepsy and explore new treatment directions This study provides an overview of the transporter proteins(acid-sensing ion channel,Na^(+)/H^(+)exchanger,Na^(+)/HCO_(3)^(−)otransporters,anion exchangers,carbonic anhydrases)and the regulation of acid-base balance in the lungs.This study also introduces how these transporters participate in the stable maintenance of brain acid-base balance and their influence in epileptogenesis from both basic and clinical aspects in detail,providing new targets for epilepsy treatment and intervention.

关 键 词：癫痫 酸碱平衡 转运蛋白 神经元 

分 类 号：R742.1[医药卫生—神经病学与精神病学]