基于Meta分析的全氟化合物对鱼类生态毒性效应  

Ecological Toxic Effect of Perfluorinated Compounds on Fish Based on Meta⁃analysis

作　　者：陆宏 周锦阳 杨帆[1,2] 王蓓莉 程治文 申哲民 袁涛[1,2] LU Hong;ZHOU Jin-yang;YANG Fan;WANG Bei-li;CHENG Zhi-wen;SHEN Zhe-min;YUAN Tao(School of Environmental Science and Engineering,Shanghai Jiao Tong University,Shanghai 200240,China;State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants,Shanghai 200240,China)

机构地区：[1]上海交通大学环境科学与工程学院,上海200240 [2]国家环境保护新型污染物环境健康影响评价重点实验室,上海200240

出　　处：《环境科学》2023年第9期5231-5241,共11页Environmental Science

基　　金：上海市2021年度“科技创新行动计划”社会发展科技攻关项目(21DZ1202100);国家自然科学基金青年科学基金项目(22106102);上海交通大学医工交叉研究基金重点项目(YG2019ZDA29)。

摘　　要：全氟及多氟化合物(PFAS)是难降解的有机污染物,具有普遍存在、生物蓄积和生物学毒性效应等特点.为探讨PFAS对鱼类的生物毒性效应,综述了64篇文献,通过Meta分析合并效应值探讨鱼类暴露于PFAS对其功能性状的毒性,为PFAS的毒性评估提供参考,有利于PFAS污染的优先控制管理.结果表明:①在研究的12种功能性状中,鱼类的7类功能性状易感,毒性响应顺序为畸形(ln RR=-2.5599)、发育(ln RR=-0.4103)、细胞损伤(ln RR=-0.3962)、生殖(ln RR=-0.3724)、甲状腺水平(ln RR=-0.2492)、生长(ln RR=-0.2194)和生存(ln RR=-0.2192);②鱼类性别和所处发育阶段显著影响PFAS的水生毒性,PFAS易对雌鱼产生不良影响(ln RR=-0.1628),且胚胎期鱼类的生理功能受PFAS影响最显著(ln RR=-0.3553);③研究涉及的PFAS共13种,其中具有磺酸盐基团的PFAS和长链PFAS更易对鱼类的功能性状产生不良影响(P<0.05);④现有数据揭示PFAS在中低浓度(0.01~10 mg·L^(-1))下易对鱼类产生急性毒性(P<0.05).Perfluoroalkyl and polyfluoroalkyl substances(PFAS)are refractory organic pollutants,which are characterized by ubiquity,bioaccumulation,and biological toxicity.To explore the biotoxic effects of PFAS on fish,this study reviewed 64 publications.The toxicity of PFAS on functional traits of fish exposed to PFAS was analyzed based on Meta⁃analysis combined with effect sizes,which provided reference for the toxicity assessment of PFAS and was conducive to the priority control and management of PFAS pollution.The results showed that:①of the 12 functional traits studied,seven were found to be vulnerable in fish;the order of toxicity response was malformation(ln RR=-2.5599),development(ln RR=-0.4103),cell damage(ln RR=-0.3962),reproduction(ln RR=-0.3724),thyroid response(ln RR=-0.2492),growth(ln RR=-0.2194),and survival(ln RR=-0.2192).②The aquatic toxicity of PFAS was significantly affected by the sex and developmental stage of fish.PFAS tended to have adverse effects on female fish(ln RR=-0.1628),and the physiological function of embryos was most significantly affected by PFAS(ln RR=-0.3553).③A total of 13 PFAS were involved in the study,among which PFAS with sulfonate groups and long⁃chains were more likely to have significant toxicity to the functional traits of fish(P<0.05).④Existing data revealed that PFAS tended to produce acute toxicity to fish at medium and low concentrations(0.01⁃10 mg·L^(-1),P<0.05).

关 键 词：全氟及多氟化合物(PFAS) 鱼类 水生环境 生态毒性 META分析 

分 类 号：X171.5[环境科学与工程—环境科学]