淋巴血浆置换对重症胰腺炎患者血清白细胞介素-17及免疫功能的影响  

Effect of lymphoplasmapheresis on serum interleukin-17 and immune function in patients with severe acute pancreatitis

作　　者：伍庆辉 喻斌[1] 尹玉婷 周军[1] 张勇[1] WU Qinghui;YU Bin;YIN Yuting;ZHOU Jun;ZHANG Yong(Department of Blood Transfusion,Pingxiang People's Hospital,Pingxiang,Jiangxi,337000,China)

机构地区：[1]萍乡市人民医院输血科,江西萍乡337000

出　　处：《当代医学》2023年第11期28-31,共4页Contemporary Medicine

摘　　要：目的探讨淋巴血浆置换对重症胰腺炎(SAP)患者血清白细胞介素-17(IL-17)、免疫功能的影响。方法选取2019年3月至2021年3月于本院治疗的80例SAP患者作为研究对象,随机分为置换组与常规组,每组40例。常规组行常规治疗,置换组在常规组基础上联合血浆置换。比较两组治疗前后免疫功能指标(IgG、IgA、IgM)、炎症因子[IL-17、肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)]水平及并发症发生情况、病情恢复情况。结果治疗前,两组IgG、IgM、IgA水平比较差异无统计学意义(P<0.05);治疗后,两组IgG、IgM、IgA水平均高于治疗前,且置换组高于常规组,差异有统计学意义(P<0.05)。治疗前,两组IL-17、IL-10、TNF-α水平比较差异无统计学意义;治疗后,两组IL-17、IL-10、TNF-α水平均低于治疗前,且置换组低于常规组,差异有统计学意义(P<0.05)。置换组并发症发生率低于常规组,差异有统计学意义(P<0.05)。置换组治疗首次排气时间、住院时间、腹痛缓解时间均短于常规组,住院时间及急性生理与慢性健康评分(APACHE-Ⅱ)低于常规组,差异有统计学意义(P<0.05)。结论采用淋巴血浆置换临床治疗SAP,能明显改善患者免疫功能,降低炎症因子水平,值得临床推广应用。Objective To investigate the effects of lymphoplasmapheresis on serum interleukin-17(IL-17)and immune function in patients with severe acute pancreatitis(SAP).Methods A total of 80 SAP patients treated in our hospital from March 2019 to March 2021 were selected as the research subjects,and they were randomly divided into the replacement group and the conventional group,with 40 cases in each group.The conventional group received routine treatment,and the replacement group was combined with plasma exchange based on the conventional group.The levels of immune function indexes(IgG,IgA,IgM),inflammatory factors(IL-17,tumor necrosis factor-α[TNF-α],interleukin-10[IL-10])before and after treatment,the occurrence of complications and the recovery of the disease were compared between the two groups.Results Before treatment,there were no significant differences in IgG,IgM and IgA levels between the two groups(P<0.05);after treatment,the levels of IgG,IgM and IgA of the two groups were higher than before treatment,and the replacement group was higher than the conventional group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in IL-17,IL-10 and TNF-αlevels between the two groups;after treatment,the levels of IL-17,IL-10 and TNF-αof the two groups were lower than those before treatment,and replacement group was lower than the conventional group,the differences were statistically significant(P<0.05).The incidence of complications in the replacement group was lower than that in the conventional group,and the difference was statistically significant(P<0.05).The first exhaust time,hospital stay and abdominal pain relief time in the replacement group were shorter than those in the conventional group,and the acute physiology and chronic health evaluation(APACHE-Ⅱ)score was lower than that in the conventional group,the differences were statistically significant(P<0.05).Conclusions The use of lymphoplasmapheresis in the clinical treatment of SAP can significantly imp

关 键 词：胰腺炎 淋巴血浆置换 免疫功能 白细胞介素-17 

分 类 号：R576[医药卫生—消化系统]