Circuit-Specific Control of Blood Pressure by PNMT‑Expressing Nucleus Tractus Solitarii Neurons  

作　　者：Shirui Jun Xianhong Ou Luo Shi Hongxiao Yu Tianjiao Deng Jinting Chen Xiaojun Nie Yinchao Hao Yishuo Shi Wei Liu Yanming Tian Sheng Wang Fang Yuan 

机构地区：[1]Department of Neurobiology,Hebei Medical University,Shijiazhuang 050017,China [2]Institute of Cardiovascular Research,Southwest Medical University,Luzhou 646000,China [3]Core Facilities and Centers,Institute of Medicine and Health,Hebei Medical University,Shijiazhuang 050017,China [4]Hebei Key Laboratory of Neurophysiology,Shijiazhuang 050017,China

出　　处：《Neuroscience Bulletin》2023年第8期1193-1209,共17页神经科学通报（英文版）

基　　金：supported by the Natural Science Foundation of China(31971050);the Natural Science Foundation of Hebei Province for Distinguished Young Scholars(H2020206509);Hebei Province Innovative Research Project for Postgraduate(2021074);the Natural Science Foundation of Hebei Province for Innovative Research Group Project(H2021206203).

摘　　要：The nucleus tractus solitarii(NTS)is one of the morphologically and functionally defined centers that engage in the autonomic regulation of cardiovascular activity.Phenotypically-characterized NTS neurons have been implicated in the differential regulation of blood pressure(BP).Here,we investigated whether phenylethanolamine N-methyltransferase(PNMT)-expressing NTS(NTS^(PNMT))neurons contribute to the control of BP.We demonstrate that photostimulation of NTS^(PNMT)neurons has variable effects on BP.A depressor response was produced during optogenetic stimulation of NTS^(PNMT)neurons projecting to the paraventricular nucleus of the hypothalamus,lateral parabrachial nucleus,and caudal ventrolateral medulla.Conversely,photostimulation of NTS^(PNMT)neurons projecting to the rostral ventrolateral medulla produced a robust pressor response and bradycardia.In addition,genetic ablation of both NTS^(PNMT)neurons and those projecting to the rostral ventrolateral medulla impaired the arterial baroreflex.Overall,we revealed the neuronal phenotype-and circuit-specific mechanisms underlying the contribution of NTS^(PNMT)neurons to the regulation of BP.

关 键 词：Nucleus tractus solitarii Blood pressure Rostral ventrolateral medulla OPTOGENETICS Neural circuit 

分 类 号：R544.1[医药卫生—心血管疾病] R692[医药卫生—内科学]