HedgeHog抑制剂靶向治疗眼周基底细胞癌1例  

HedgeHog inhibitor targeted therapy for periocular basal cell carcinoma:a case report

作　　者：陈婕 许诗琼[1] 贾仁兵[1] 范先群[1] Chen Jie;Xu Shiqiong;Jia Renbing;Fan Xianqun

机构地区：[1]上海交通大学医学院附属第九人民医院眼科、上海市眼眶病眼肿瘤重点实验室,上海200011

出　　处：《中华眼科杂志》2023年第9期748-750,共3页Chinese Journal of Ophthalmology

基　　金：上海市科学技术委员会基础重点研究项目(22Y31900700);上海高校高水平创新团队建设项目(SHSMU-ZDCX20210902);上海市卫生健康委员会课题(2022YQ01)。

摘　　要：患者女性,87岁。发现左眼内眦不规则肿物7年。患者身体状况不适合行根治性手术。手术活体组织检查确诊左眼内眦基底细胞癌。患者口服HedgeHog抑制剂靶向治疗6个月,肿瘤体积减小约90%,病情改善,肿瘤稳定,持续随访。A female patient,87 years old,presented with an irregular swelling in the left medial canthus for 7 years.Due to the patient′s poor general condition,radical surgery was not considered appropriate.Surgical biopsy confirmed periocular basal cell carcinoma of the left medial canthus.The patient was administered oral HedgeHog inhibitor targeted therapy for 6 months,resulting in approximately 90%reduction in tumor size.The patient′s condition improved,and the tumor remained stable during the course of follow-up.

关 键 词：眼肿瘤 癌 基底细胞 猬蛋白质类 抗肿瘤药 信号传导 联苯化合物 吡啶类 分子靶向治疗 

分 类 号：R739.7[医药卫生—肿瘤]