检索规则说明:AND代表“并且”;OR代表“或者”;NOT代表“不包含”;(注意必须大写,运算符两边需空一格)
检 索 范 例 :范例一: (K=图书馆学 OR K=情报学) AND A=范并思 范例二:J=计算机应用与软件 AND (U=C++ OR U=Basic) NOT M=Visual
作 者:商慧鲜 许宏侠 SHANG Hui-xian;XU Hong-xia(Department of Geriatrics,the First Affiliated Hospital of Henan University,Kaifeng 475001,China)
机构地区:[1]河南大学第一附属医院老年病科,开封475001
出 处:《四川解剖学杂志》2023年第2期45-47,共3页Sichuan Journal of Anatomy
基 金:河南省科技攻关计划联合共建项目(LHGJ20190505)资助。
摘 要:目的:探讨血浆中脂蛋白相关磷脂酶A2(Lp-PLA2)、8-羟基脱氧鸟苷酸(8-OHdG)水平表达对阿尔茨海默病(AD)患者的临床意义.方法:选取本院2019年8至2022年7月收治的148例AD患者作为AD组,另选取同期137例健康志愿者作为对照组.比较AD组与对照组Lp-PLA2、8-OHdG水平、睡眠质量及认知功能.比较不同睡眠质量及不同程度认知障碍AD患者的Lp-PLA2、8-OHdG水平.结果:AD组Lp-PLA2、8-OHdG水平高于对照组,差异有统计学意义(P<0.05);AD组蒙特利尔认知评估量表(MoCA)评分低于对照组,匹兹堡睡眠质量指数量表(PSQI)评分高于对照组,差异有统计学意义(P<0.05).有睡眠障碍的AD患者Lp-PLA2、8-OHdG水平均高于无睡眠障碍的AD患者,差异有统计学意义(P<0.05);随着的AD患者认知障碍程度的加重,Lp-PLA2、8-OHdG水平逐渐上升,差异有统计学意义(P<0.05).结论:AD患者Lp-PLA2、8-OHdG高水平者出现睡眠障碍及认知功能障碍风险相对更高,通过检测Lp-PLA2、8-OHdG水平可为早期诊治提供依据.Objective:To investigate clinical significance of the expression of lipoprotein related phospholipase A2(Lp-PLA2)and 8-hydroxydeoxyguanylic acid(8-OHdG)levels in plasma in patients with Alzheimer's disease(AD).Methods:A total of 148 AD patients admitted to our hospital from August 2019 to July 2022 were selected in the study and included into AD group.Additionally,137 healthy volunteers were selected and included into control group.The levels of Lp-PLA2,8-OHdG,sleep quality,and cognitive function were compared between the AD group and the control group.And the levels of Lp-PLA2 and 8-OHdG in AD patients with different sleep quality and different degrees of cognitive impairment were compared.Results:The levels of Lp-PLA2 and 8-OHdG in the AD group were higher than those in the control group(P<0.05).The MoCA score of the AD group was lower than that of the control group,and the PSQI score was higher than that of the control group(P<0.05).The levels of Lp-PLA2 and 8-OHdG in the AD patients with sleep disorder were higher than those in the AD patients without sleep disorder(P<0.05).As the degree of cognitive impairment worsens,the levels of Lp-PLA2 and 8-OHdG gradually increase(P<0.05).Conclusion:AD patients with high levels of Lp-PLA2 and 8-OHdG have a relatively higher risk of sleep disorders and cognitive impairment.Detecting the levels of Lp-PLA2 and 8-OHdG can provide a basis for early diagnosis and treatment.
关 键 词:阿尔茨海默病 脂蛋白相关磷脂酶A2 8-羟基脱氧鸟苷酸 临床意义
分 类 号:R749.16[医药卫生—神经病学与精神病学]
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在链接到云南高校图书馆文献保障联盟下载...
云南高校图书馆联盟文献共享服务平台 版权所有©
您的IP:216.73.216.7