血清维生素D_(3)、血清游离轻链、血清游离轻链比在多发性骨髓瘤诊断中的临床意义  

Clinical Significance of Serum Vitamin D_(3)Serum Free Light Chain,Ratio of Free Light Chain in the Diagnosis of Multiple Myeloma

作　　者：王振兴[1] 王杰[1] 刘福莲 陈素芳[2] WANG Zheng-xing;WANG Jie;LIU Fu-lian;CHEN Su-fang(Department of Blood Endocrinology,the 83rd Group Military Hospital of the Chinese People's Liberation Army,Xinxiang 453001,China;Department of Respiratory Medicine,the 83rd Group Military Hospital of the Chinese People's Liberation Army,Xinxiang 453001,China)

机构地区：[1]中国人民解放军陆军第83集团军医院血液内分泌科,新乡453001 [2]中国人民解放军陆军第83集团军医院呼吸内科,新乡453001

出　　处：《四川解剖学杂志》2023年第2期60-62,共3页Sichuan Journal of Anatomy

摘　　要：目的:分析维生素D_(3)、血清游离轻链(sFLC)、血清游离轻链比(rFLC)在多发性骨髓瘤诊断中的临床意义.方法:选取本院2018年6月至2022年9月收治的81例多发性骨髓瘤患者作为观察组,另选本院同期进行体检且各项指标正常的78例志愿者为对照组.比较两组血清维生素D_(3)、sFLC、rFLC水平,分析血清维生素D_(3)、sFLC、rFLC单一检测与联合检测多发性骨髓瘤的敏感性、特异性及准确性.结果:观察组血清维生素D_(3)、sFLC、rFLC水平均高于对照组,差异有统计学意义(P<0.05).观察组患者治疗后的血清维生素D_(3)、sFLC、rFLC水平均有所下降,差异有统计学意义(P<0.05).多发性骨髓瘤Ⅱ~Ⅲ期患者的血清维生素D_(3)、sFLC、rFLC水平显著高于Ⅰ期,差异有统计学意义(P<0.05).联合检测的敏感性(91.36%)、特异性(97.44%)及准确性(94.34%)均高于单一检测.结论:血清维生素D_(3)、sFLC、rFLC与多发性骨髓瘤的发生有一定的相关性,联合检测准确性较高,可用于诊断多发性骨髓瘤.Objective:To analyze clinical significance of vitamin D_(3),serum free light chain(sFLC)and ratio of free light chain(rFLC)in the diagnosis of multiple myeloma.Methods:A total of 81 patients with multiple myeloma who were treated in our hospital from June 2018 to September 2022 were selected as the observation group,another 78 volunteers who underwent physical examination in the same period with normal indicators in our hospital were selected as the control group.The levels of serum vitamin D,,sFLC,and rFLC among different groups were compared,and the sensitivity,specificity,and accuracy of single and combined detection of vitamin D_(3),sFLC,and rFLC were analyzed.Results:The levels of serum vitamin D_(3),sFLC and rFLC in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of serum vitamin D_(3),sFLC,and rFLC in the observation group were all decreased(P<0.05).The serum vitamin D_(3),sFLC,rFLC levels inⅡ~Ⅲstage of multiple myeloma were significantly higher than those in I stage(P<0.05).The sensitivity was 91.36%,the specificity(97.44%)and the accuracy(94.34%)of the joint detection were significantly higher than those of the single detection.Conclusions:There is a certain correlation between vitamin Ds,sFLC,rFLC,and the occurrence of multiple myeloma.The combined detection has high accuracy and can be used for the diagnosis of multiple myeloma,which is worthy of clinical application.

关 键 词：血清维生素D3 血清游离轻链 血清游离轻链比 多发性骨髓瘤 

分 类 号：R733.3[医药卫生—肿瘤]