Seroprevalence of human enterovirus A71 in Guangzhou,China,2019-2021  

作　　者：Huimin Lian Huimin Jianng Lina Yi Jing Sun Huaping Xie Ming Qiu Limei Sun Huifang Lin Mingda Yang Lin Qu Haiyi Yang Jing Lu Hanri Zeng 

机构地区：[1]School of Public Health,Southern Medical University,Guangzhou 510515,China [2]Guangdong Provincial Institution of Public Health,Guangdong Provincial Center for Disease Control and Prevention,Guangzhou 511430,China [3]Guangdong Workstation for Emerging Infectious Disease Control and Prevention,Guangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease Response,Guangdong Provincial Center for Disease Control and Prevention,Guangzhou 511430,China [4]Health Commission of Heping District,Shenyang City,Liaoning 110003,China [5]Guangzhou Center for Disease Control and Prevention,Guangzhou 510440,China [6]School of Public Health,Sun Yat-Sen University,Guangzhou 510080,China [7]School of Public Health,Jinan University,Guangzhou 510632,China

出　　处：《Biosafety and Health》2023年第3期168-173,共6页生物安全与健康（英文）

基　　金：supported by the Guangzhou Science and Technol-0gy Planning Project(202002030099);the Natural Science Foundation of Guangdong Province(2023A1515011927).

摘　　要：Enterovirus A71 (EV-A71) is a significant hand-foot-mouth disease (HFMD) etiology. The inactivated EV-A71 vaccines were approved in China in 2016. However, the seroprevalence of EV-A71 after the vaccine application and its potential association with the EV-A71 epidemic in the population are rarely studied. In this study, we analyzed the incidence of EV-A71 infection and seroepidemiology in Guangzhou City, China. From 2019 to 2021, 167,920 clinically confirmed HFMD cases were reported in Guangzhou. In 6,868 enterovirus-positive samples, Coxsackievirus A6 and Coxsackievirus A16 were dominant genotypes, and only 3 EV-A71-positive samples were detected, highlighting the deficient epidemic activity of EV-A71. Microneutralization assay was performed on 1,000 representative serum samples. Notably, the seroprevalence and geometric mean titer (GMT) decreased significantly in 2020, and that in the < 3-year age group were increased and even higher than that in 3–5-year age group in 2019 and 2021, which was contrary to our previous surveillance result and other studies in Guangzhou. Furthermore, a moderate decline of GMT level was observed following the vaccination, but the seropositive serums were still detected for 49 months after second immunization, suggesting the long-term persistence of the immunity. Our seroepidemiology study revealed relatively higher neutralizing antibody activity in the susceptible population after the EV-A71 vaccine was adopted in 2016 in Guangzhou. It may be one of the reasons for the lower epidemic activity of EV-A71 in Guangzhou from 2019 to 2021.

关 键 词：Enterovirus A71 VACCINE SEROEPIDEMIOLOGY 

分 类 号：R725.1[医药卫生—儿科]