静脉血栓栓塞症患者随访期癌症发生率及发病特征研究  

Cancer incidence and characteristics in patients with venous thromboembolism during follow-up

作　　者：李研[1,2] 张宇 翟振国 谢万木[2] 张竹[2] LI Yan;ZHANG Yu;ZHAI Zhenguo;XIE Wanmu;ZHANG Zhu(Beijing Hepingli Hospital,Beijing 100013,China;Department of Pulmonary and Critical Care Medicine,Center of Respiratory Medicine,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]北京市和平里医院,北京100013 [2]中日友好医院呼吸中心呼吸与危重症医学科,北京100029

出　　处：《临床肺科杂志》2023年第10期1459-1464,1478,共7页Journal of Clinical Pulmonary Medicine

摘　　要：目的了解我国静脉血栓栓塞症(VTE)患者在随访期癌症的发病情况。方法连续入组2018年在中日友好医院住院诊断为VTE的患者,按危险因素分组,比较组间新发癌症发病风险的差异。结果纳入患者521例(其中42例失访),男249例,女272例,中位年龄66岁。无诱因VTE 305例(58.5%),已知危险因素VTE 216例(41.5%),中位随访时间为28(24~31)个月,在随访期有56例(10.7%)确诊癌症,最长的诊断时间为28个月。其中51例(91.1%)在VTE后12个月内被诊断,新发癌症的发生率在12个月时为10.9%。发生的所有癌症中最常见的是肺癌(29例,51.8%)。结论1.VTE患者在1年随访期内癌症的发生率为10.9%,2年为11.9%。其中91.1%在1年内诊断;2.无诱因VTE患者较已知危险因素的VTE患者在随访期癌症发生率更高。Objective To investigate the incidence of cancer in Chinese patients with venous thromboembolism(VTE)during follow-up.Methods The patients were admitted to China-Japan Friendship Hospital and diagnosed as VTE patients from January 1,2018 to December 31,2018.According to the risk factors,they were divided into two groups.The statistical differences in cancer incidence among the groups were compared.Results A total of 521 patients were included,including 249 males and 272 females,with a median age of 66 years old.There were 305 cases(58.5%)of unprovoked VTE,and 216 cases(41.5%)of provoked VTE,with the median follow-up of 28 months(24-31).56 cases(10.7%)were diagnosed with cancer during the follow-up period,with the longest diagnosis time being 28 months.51 cases(91.1%)were diagnosed within 12 months of VTE,and the incidence of new cancers using survival analysis was 10.9%at 12 months.Of all cancer,the most common type was lung cancer(29 cases,51.8%).Conclusion 1.The incidence of cancer in patients with VTE is 10.9%at 1 year and 11.9%at 2 years,and 91.1%of them are diagnosed within 1 year.2.Patients with uninduced VTE have a higher incidence of cancer during follow-up than patients with known risk factors for VTE.

关 键 词：静脉血栓栓塞症 癌症 发病风险 

分 类 号：R730[医药卫生—肿瘤] R543.6[医药卫生—临床医学]