肿瘤标志物联合超声及ROMA指数对卵巢恶性肿瘤的预测作用  

Predictive effect of tumor markers combined with ultrasound and ROMA index on ovarian malignancy

作　　者：周玉[1] 郑轶[1] 王玲玲[1] 刘淑玉[1] 翁文娟 王才智[1] ZHOU Yu;ZHENG Yi;WANG Ling-ling;LIU Shu-yu;WENG Wen-juan;WANG Cai-zhi(Department of Obstetrics and Gynecology,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004,China)

机构地区：[1]蚌埠医学院第一附属医院妇产科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2023年第9期1208-1210,1214,共4页Journal of Bengbu Medical College

基　　金：安徽省高校自然科学研究重点项目(KJ2021A0754);蚌埠医学院科技发展基金项目(2021byzd088)。

摘　　要：目的:探讨肿瘤标志物联合超声及恶性肿瘤风险模型(ROMA)指数对卵巢恶性肿瘤的预测作用。方法:回顾性分析197例因盆腔肿物进行手术病人,依据术后病理报告,112例为卵巢良性病变(良性组),85例为卵巢恶性病变(恶性组)。对2组病人癌抗原(CA)125、CA153、CA199、甲胎蛋白、癌胚抗原、人附睾蛋白4(HE4)测定结果和超声检查结果、ROMA指数进行统计分析,分析其对卵巢恶性肿瘤的预测作用。结果:超声诊断卵巢良性病变,准确率达90%以上;卵巢恶性病变组中CA125、CA153、HE4及ROMA指数较卵巢良性病变组升高,差异均有统计学意义(P<0.01);CA125、HE4对卵巢良恶性病变诊断预测价值较高;CA125、HE4、ROMA指数、超声四种指标联合使用对卵巢恶性病变检测的敏感性、特异性、阳性预测值、阴性预测值均较高,大于94%。结论:CA125、HE4、ROMA指数及妇科超声联合对卵巢恶性病变诊断敏感性、特异性、阳性预测值、阴性预测值较高,可作为预测卵巢恶性病变的重要手段。Objective:To investigate the predictive effect of tumor markers combined with ultrasound and risk of ovarian malignancy algorithm(ROMA)index on ovarian malignancy.Methods:One hundred and ninety-seven patients were operated for pelvic mass.According to the postoperative pathological reports,112 were benign ovarian lesions(benign group)and 85 were malignant ovarian lesions(malignant group).The results of CA125,CA153,CA199,CA 199,AFP,CEA,HE4,ultrasound findings and ROMA index were analyzed to determine their predictive effect on ovarian malignancy.Results:Ultrasound diagnosed benign ovarian lesions with an accuracy of more than 90%.CA125,CA153,HE4 and ROMA index increased than benign ovarian lesions(P<0.01).CA125 and HE4 showed the higher sensitivity,specificity,positive predictive value and negative predictive value of ovarian malignant lesions with more than 94%.Conclusions:The combination of CA125,HE4,ROMA index and gynecological ultrasound has the high sensitivity,specificity,positive predictive value and negative predictive value for the diagnosis of ovarian malignant lesions,which can be used as an important markers to predict the malignant ovarian lesions.

关 键 词：卵巢恶性肿瘤 肿瘤标志物 ROMA指数 

分 类 号：R737.33[医药卫生—肿瘤]