早产儿视网膜病变患儿屈光不正的机制研究进展  

Research progress on the pathogenesis of refractive errors in retinopathy of prematurity

作　　者：杨佳洁 马继贤 田思雯 李晶明[2] 刘秋平[1] YANG Jiajie;MA Jixian;TIAN Siwen;LI Jingming;LIU Qiuping(Department of Ophthalmology,the Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China;Department of Ophthalmology,the First Affiliated Hospital of Xi’an Jiao Tong University,Xi’an 710061,Shaanxi Province,China)

机构地区：[1]南昌大学附属眼科医院眼科,江西省南昌市330006 [2]西安交通大学第一附属医院眼科,陕西省西安市710061

出　　处：《眼科新进展》2023年第10期823-827,共5页Recent Advances in Ophthalmology

基　　金：国家自然科学基金(编号:81960177);江西省卫生健康委员会科技计划项目(编号:202210723)。

摘　　要：早产儿视网膜病变(ROP)是发生于早产儿的未成熟视网膜血管的异常增生性疾病,是目前婴幼儿致盲的主要原因之一。无论是否接受治疗,ROP患儿发生屈光不正(尤其是近视和散光)的概率均较高,发生屈光不正性弱视、斜视等视觉异常的危险性高,这为临床上ROP的治疗及屈光不正的矫正提出了挑战。然而,目前ROP患儿屈光不正的发病机制尚未完全阐明,本文旨在对目前提出的相关机制进行综述,从而为临床上优化ROP屈光不正的矫治方式提供理论基础。Retinopathy of prematurity(ROP)is a proliferative disorder of immature retinal blood vessels in preterm infants,which is one of the main causes of blindness in infants.Regardless of treatment or not,ROP patients are very likely to develop refractive errors(especially myopia and astigmatism),and the risk of visual abnormalities such as ametropic amblyopia and strabismus is high,which poses a challenge for the treatment of ROP and the correction of refractive errors in clinical practice.However,the pathogenesis of refractive errors in children with ROP is still unclear and has not been fully elucidated.This article aims to review the research findings on the pathogenesis,so as to provide a theoretical basis for optimizing the clinical treatment of refractive errors in ROP.

关 键 词：早产儿视网膜病变 屈光不正 多巴胺 近视 

分 类 号：R774.1[医药卫生—眼科]