肺微小脑膜上皮样结节——认知进展与争论  

Recent Advances and Controversies in Minute Pulmonary Meningothelial-like Nodules

作　　者：李昊辰 薛剑超 李盼 徐源[1] 郑志博 李单青 梁乃新[1] Haochen LI;Jianchao XUE;Pan LI;Yuan XU;Zhibo ZHENG;Shanqing LI(Naixin LIANG11Department of Thoracic Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China;School of Medicine,Tsinghua University,Beijing 100084,China;Department of Pathology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China;Department of International Medical Services,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医院胸外科,北京100730 [2]清华大学医学院,北京100084 [3]中国医学科学院北京协和医院病理科,北京100730 [4]中国医学科学院北京协和医院国际医疗部,北京100730

出　　处：《中国肺癌杂志》2023年第8期621-629,共9页Chinese Journal of Lung Cancer

基　　金：希思科-默沙东肿瘤研究基金项目(No.CSCO-Y-MSDPU2021-0190);中央高水平医院临床科研业务费(No.2022-PUMCH-A-106,No.2022-PUMCH-B-011)资助。

摘　　要：肺微小脑膜上皮样结节(minute pulmonary meningothelial-like nodules,MPMNs)是一种与脑膜上皮有相似病理学特征的肺部良性小病灶,和恶性肿瘤有相似的影像学表现,可在临床上导致误诊。关于MPMNs的发病机制尚未达成共识,有观点认为MPMNs可能是一种反应性增生,也有观点认为MPMNs与中枢神经系统脑膜瘤有共同的起源和分子机制。了解MPMNs的特征,深入研究其发病机制,有助于提高对该病的认识和诊断水平。本文就MPMNs的临床、病理、影像学特点以及鉴别诊断和发病机制进行综述,并全面分析了其发病机制的研究进展,对进一步探索提出展望。Minute pulmonary meningothelial-like nodules(MPMNs)are benign small lesions in the lungs,with similar pathological characteristics to the meningeal epithelium.MPMNs have similar imaging manifestations to malignant tumors,which can lead to misdiagnosis in clinical practice.There is no consensus on the pathogenesis of MPMNs,with some suggest that MPMNs derive from reactive proliferation,while others suggest that MPMNs share a common origin and molecular mechanism with meningiomas in the central nervous system.Understanding the characteristics of MPMNs and studying their pathogenesis will help improve the understanding and diagnosis of MPMNs.In this article,we reviewed the clinical,pathological,imaging characteristics,differential diagnosis and pathogenesis of MPMNs.We also analyze the existing research advances regarding the pathogenesis and propose prospects for further research.

关 键 词：肺微小脑膜上皮样结节 脑膜瘤 肺肿瘤 多原发肺癌 

分 类 号：R734.2[医药卫生—肿瘤]