影像计划和实时引导肺癌穿刺活检在生物标志物检测中的进展  

Progress in Image-planned and Real-time Image-guided Lung Cancer Biopsy in the Detection of Biomarkers

作　　者：白庚申 朱炳印 马军 李永春 黄刚[2] 马娅琼[2] Gengshen BAI;Bingyin ZHU;Jun MA;Yongchun LI;Gang HUANG;Yaqiong MA(Department of Interventional,Baiyin Second People's Hospital,Baiyin 730900,China;Department of Radiology,Gansu Provincial Hospital,Lanzhou 730030,China)

机构地区：[1]白银市第二人民医院介入科,白银730900 [2]甘肃省人民医院放射科,兰州730030

出　　处：《中国肺癌杂志》2023年第8期630-638,共9页Chinese Journal of Lung Cancer

基　　金：甘肃省人民医院科研基金项目(No.20GSSY2-1);甘肃省自然科学基金项目(No.21JR7RA605)资助。

摘　　要：随着肺癌个体化治疗的进展,临床对肺癌穿刺活检样本的要求越来越高。一个理想的肺癌活检样本不仅可以实现组织病理学诊断,还能够用于生物标志物检测。理想的活检样本需符合至少60 mm2的肿瘤组织和其内的瘤细胞占比在20%以上。要想获取理想的肺癌穿刺活检样本,就需要先进的影像技术予以帮助。本文就基于生物标志物检测对活检样本的要求及影像在肺癌穿刺活检术前计划穿刺路径及术中实时引导穿刺活检的现状和研究进展予以综述。With the progress of targeted therapy and immunotherapy for lung cancer,the clinical demand for lung biopsy is increasing.An ideal biopsy specimen can be used not only for histopathological diagnosis,but also for biomarker detection.The ideal biopsy specimen should meet two requirements,including more than 60 mm2 of tumor tissue and containing more than 20%of tumor cells.In order to obtain ideal lung cancer biopsy specimens,advanced imaging techniques are needed to help.In this article,we reviewed the requirements for biopsy specimens based on biomarker detection,as well as the current status and research progress of using imaging techniques for preoperative planning and intraoperative real time guidance of lung cancer biopsy.

关 键 词：肺肿瘤 活检 生物标志物检测 影像 

分 类 号：R734.2[医药卫生—肿瘤]