非肥胖女性OSAHS患者慢波睡眠与TyG指数的相关性研究  

Association between slow wave sleep and triglyceride-glucose index innon-obese women with obstructive sleep apnea-hypopnea syndrome

作　　者：潘启源 李瀚卿 甘谢雨 陈欣[1] 刘希睿 李晋芳[1] PAN Qiyuan;LI Hanqing;GAN Xieyu;CHEN Xin;LIU Xirui;LI Jinfang(Department of Neurology,The Second Hospital of Chongqing Medical University,Chongqing 400010,China;Department of Stomatology,Zaoyang First People’s Hospital,Zaoyang,Hubei 441200,China)

机构地区：[1]重庆医科大学附属第二医院神经内科,重庆400010 [2]枣阳市第一人民医院口腔科,湖北枣阳441200

出　　处：《重庆医学》2023年第18期2834-2838,共5页Chongqing medicine

基　　金：重庆市科卫联合医学科研项目(2021MSXM339)。

摘　　要：目的 探讨非肥胖女性阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者慢波睡眠(SWS)与葡萄糖甘油三酯(TyG)指数的关联,为OSAHS的预防及干预提供医学参考。方法 回顾性纳入重庆医科大学附属第二医院2013年2月至2021年10月收治的64例非肥胖女性OSAHS患者,采用Spearman相关性分析显示SWS和TyG指数的相关性。逐步线性回归分析影响患者呼吸暂停低通气指数(AHI)和SWS的独立危险因素。结果 Spearman相关性分析显示SWS与AHI呈正相关(r=0.385,P=0.002),偏相关分析显示SWS与AHI呈正相关(r=0.427,P=0.001)。TyG指数与AHI呈正相关(r=0.273,P=0.029),逐步线性回归分析显示SWS是AHI的独立危险因素(P<0.05)。进一步相关性分析显示TyG指数与SWS呈正相关(r=0.394,P=0.001)。逐步线性回归分析显示TyG指数是SWS的独立危险因素(P<0.05)。结论 在非肥胖女性OSAHS患者中,SWS与TyG指数独立相关,二者均可反映疾病的严重程度。Objective To investigate the relationship between slow wave sleep(SWS)and triglyceride-glucose(TyG)index in non-obese women with obstructive sleep apnea-hypopnea syndrome(OSAHS),and provide medical reference for OSAHS prevention and intervention.Methods A total of 64 non-obese female OSAHS patients who underwent polysomnography monitoring in the Second Affiliated Hospital of Chongqing Medical University from February 2013 to October 2021 were retrospectively included.Spearman correlation analysis was used to analyze the correlation between SWS and TyG index.Stepwise linear regression analysis was used to analyze the independent risk factors of apnea-hypopnea index(AHI)and SWS.Results Spearman correlation analysis showed that SWS was positively correlated with AHI(r=0.385,P=0.002),while partial correlation analysis showed that SWS was still positively correlated with AHI(r=0.427,P=0.001).In addition,the TyG index was positively correlated with AHI(r=0.273,P=0.029).The stepwise linear regression showed that SWS was an independent risk factor for AHI(P<0.05).Further correlation analysis showed that TyG index was positively correlated with SWS(r=0.394,P=0.001).Stepwi se linear regression showed that TyG index was an independent risk factor for SWS(P<0.05).Conclusion In non-obese women with OSAHS,SWS is independently correlated with TyG index,both of which can reflect the severity of the disease.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 呼吸暂停低通气指数 葡萄糖甘油三酯指数 慢波睡眠 

分 类 号：R741[医药卫生—神经病学与精神病学]