LncRNA在缺血性脑卒中血脑屏障损伤中的研究进展  

Research progress of LncRNA on blood-brain barrier in ischemic stroke

作　　者：胡云[1] 周礼鑫 童理 李鑫泰(综述) 杨剑文(审校) HU Yun;ZHOU Lixin;TONG Li;LI Xintai;YANG Jianwen(Department of NeurologyⅢ,The First Affiliated Hospital of Hunan Normal University/Hunan Provincial People’s Hospital,Changsha,Hunan 410000,China)

机构地区：[1]湖南师范大学附属第一医院/湖南省人民医院神经内三科,长沙410000

出　　处：《重庆医学》2023年第18期2864-2868,共5页Chongqing medicine

基　　金：湖南省卫生健康委科研计划项目(202203072442);湖南省教育厅科学研究项目(20C1135)。

摘　　要：缺血性脑卒中(IS)是全球范围内致残和致死的主要疾病之一,该病的病因及发病机制复杂,其中血脑屏障的破坏会加重缺血性脑卒中的进展。血脑屏障是以脑微血管内皮细胞为核心所形成的重要结构,其完整性在维持中枢神经系统微环境稳态中起着至关重要的作用。同样,血脑屏障破坏是IS进展的关键因素。作为调节IS血脑屏障的重要因子,长链非编码RNA(LncRNA)可以通过多种方式影响血脑屏障的结构和功能。该文回顾了有关LncRNA在IS血脑屏障损伤中的作用的相关研究,探讨了LncRNA作为新型生物标志物和治疗剂的潜在临床价值。Ischemia stroke(IS)is one of the leading causes of disability and death worldwide.The etiology and pathogenesis of this disease are complicated,and the destruction of blood-brain barrier(BBB)would aggravate the progression of ischemic stroke.The blood-brain barrier is an important structure formed by cerebral microvascular endothelial cells as the core,and its integrity plays a crucial role in maintaining the homeostasis of the central nervous system microenvironment.Similarly,BBB destruction is a key element in the progression of ischemic stroke.As an important factor regulating the blood-brain barrier in ischemic stroke,Long non-coding RNA(LncRNA)can affect the structure and function of the blood-brain barrier in a variety of ways.In this review,we reviewed relevant studies on the role of LncRNAon the blood-brain barrier in ischemic stroke,and we also discussed their potential clinical applications as novel biomarkers and therapeutic agents.

关 键 词：长链非编码RNA 缺血性脑卒中 血脑屏障 脑微血管内皮 周细胞 

分 类 号：R743[医药卫生—神经病学与精神病学]