铁氧体磁芯磁场分布的优化及其对磁纳米热疗的影响  

Optimization for magnetic field distribution in ferrite core and its effect on magnetic hyperthermia

作　　者：汤云东[1] 陈泓霖 高跃明[1] TANG Yundong;CHEN Honglin;GAO Yueming(School of Physics and Information Engineering,Fuzhou University,Fuzhou 350108,China)

机构地区：[1]福州大学物理与信息工程学院,福建福州350108

出　　处：《中南大学学报（自然科学版）》2023年第8期3079-3089,共11页Journal of Central South University:Science and Technology

基　　金：国家自然科学基金资助项目(62071124);福建省自然科学基金资助项目(2020J01464);福建省科技计划项目(2021I0005)。

摘　　要：以缠绕着载流线圈的铁氧体磁芯为基础,应用有限元方法分析载流线圈位置对磁场分布的影响,接着采用磁场不均匀性函数结合遗传算法对磁芯气隙内的磁场均匀度进行优化,优化后的磁芯磁场通过顺序耦合方式被进一步应用于磁热疗治疗温度分布分析,采用治疗期间肿瘤区域内的有效治疗温度对肿瘤体积的占比来评估磁热疗治疗效果。研究结果表明:线圈位于气隙两端所产生的磁场优于其位于左端所产生的磁场,与等效磁路分析结果基本一致。本文所提优化方法可使得气隙磁场均匀度显著提高,并使磁热疗肿瘤区域最高治疗温度达到临界值,显著提高治疗效果。The effect of the position of the current-carrying coil on magnetic field distribution was analyzed by using finite element method for the ferrite core wound with the current-carrying coil.The magnetic field inhomogeneity function combined with the finite element method was then used to optimize the magnetic field uniformity for the air gap of ferrite core.The optimized magnetic field of ferrite core was further applied to the temperature distribution analysis for magnetic hyperthermia by a sequential coupling method.The therapeutic effect for magnetic hyperthermia was evaluated by using the percentage of the effective temperature volume to the tumor volume during treatment period.The results show that the magnetic field for the air gap with the coil at both ends is better than the case at the left end in ferrite core,which is basically consistent with the analysis of equivalent magnetic circuit.In addition,the optimization method proposed in this study can significantly improve the uniformity of the air-gap magnetic field,can also locate the maximum treatment temperature to a critical treatment value inside tumor region,and ultimately improve the treatment effect for magnetic hyperthermia.

关 键 词：磁热疗 磁场 铁氧体 有限元方法 生物传热方程 

分 类 号：Q819[生物学—生物工程]