肺动脉高压动物模型及其在药物研究中的应用进展  

Animal Models of Pulmonary Arterial Hypertension and Their Application in Drug Research

作　　者：俞佳慧 巩倩 庄乐南 YU Jiahui;GONG Qian;ZHUANG Lenan(Department of Veterinary Medicine,College of Animal Science,Zhejiang University,Hangzhou 310058,China;Department of Cardiology,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Key Laboratory of Cardiovascular Intervention and Regeneration Medicine of Zhejiang Province,Hangzhou 310016,China;Institute of Animal Genetics,Breeding and Reproduction,College of Animal Science,Zhejiang University,Hangzhou 310058,China)

机构地区：[1]浙江大学动物科学学院动物医学系,杭州310058 [2]浙江大学医学院附属邵逸夫医院心内科,浙江省心血管介入与再生修复研究重点实验室,杭州310016 [3]浙江大学动物科学学院动物遗传育种与繁殖研究所,杭州310058

出　　处：《实验动物与比较医学》2023年第4期381-397,共17页Laboratory Animal and Comparative Medicine

基　　金：国家重点研发计划发育编程及其代谢调节重点专项“重大人类发育性疾病猪模型的建立及发病机理研究”(2021YFA0805902);国家自然科学基金项目“Txlnb通过调控Parkin促进心肌细胞线粒体自噬与稳态维持的机制研究”(32270884)。

摘　　要：肺动脉高压是一种由肺血管重构引起血管阻力增大的临床综合征,若不治疗将导致右心衰竭,甚至死亡。目前关于肺动脉高压的病理机制尚未明确,且临床治疗方法未能有效改善预后或降低死亡率。为了深入研究肺动脉高压的发病机制并开发更加安全有效的药物,建立合适的疾病动物模型在临床前研究中必不可少。本文概述了肺动脉高压的病理特征,并总结了各类肺动脉高压动物模型,同时阐述了近5年内肺动脉高压动物模型在3种治疗途径及相关药物研究中的应用进展,以期为肺动脉高压动物模型的选择和研究应用提供参考。Pulmonary arterial hypertension is a clinical syndrome characterized by pulmonary vascular remodeling causing increased vascular resistance,which will lead to right heart failure and even death if left untreated.The pathogenesis of pulmonary arterial hypertension has not yet been clarified,and clinical treatments have not been effective in improving prognosis or reducing mortality.To investigate the pathogenesis of pulmonary arterial hypertension and to develop and evaluate more effective and safer drug treatments,establishing related animal disease models is very important.This paper outlines the pathological characteristics of pulmonary arterial hypertension and summarizes the various types of animal models of pulmonary arterial hypertension,as well as describes the progress of the application of these models in three therapeutic pathways and related drug research in the past five years,with a view to providing a reference for the selection of animal models of pulmonary arterial hypertension and research applications.

关 键 词：肺动脉高压 动物模型 药物评估 

分 类 号：R-332[医药卫生] Q95-33[生物学—动物学]