注射用红花黄色素联合丁苯酞氯化钠注射液治疗急性脑梗死的疗效分析  

Analysis of the curative effect of safflower yellow injection combined with butylphthalein and sodium chloride injection on acute cerebral infarction

作　　者：王莹莹 WANG Ying-ying(Chaoyang Second Hospital,Chaoyang 122000,China)

机构地区：[1]朝阳市第二医院,122000

出　　处：《中国现代药物应用》2023年第18期100-103,共4页Chinese Journal of Modern Drug Application

摘　　要：目的研究注射用红花黄色素联合丁苯酞氯化钠注射液治疗急性脑梗死(ACI)患者的效果。方法113例急性脑梗死患者,根据随机数字表法分为对照组(56例)和观察组(57例)。对照组患者给予常规神经内科方案和丁苯酞氯化钠注射液治疗,观察组患者在对照组基础上加用注射用红花黄色素治疗。比较两组患者的治疗效果、不良反应发生情况、美国国立卫生研究院卒中量表(NIHSS)评分、血液流变学指标。结果治疗14 d后,观察组NIHSS评分(4.20±0.44)分低于对照组的(6.21±0.57)分,差异有统计学意义(P<0.05)。治疗14 d后,观察组血浆粘度、红细胞压积、纤维蛋白原水平分别为(1.50±0.14)mPa·s、(0.34±0.05)、(3.10±0.25)g/L,均显著低于对照组的(1.79±0.17)mPa·s、(0.42±0.07)、(3.31±0.28)g/L,差异有统计学意义(P<0.05)。观察组治疗总有效率96.49%高于对照组的85.71%,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论注射用红花黄色素与丁苯酞氯化钠注射液联合治疗急性脑梗死效果肯定,有助于促进患者血液流变学的改善,修复神经功能,且安全性较高。Objective To study the effect of safflower yellow injection combined with butylphthalein and sodium chloride injection on patients with acute cerebral infarction(ACI).Methods A total of 113 patients with acute cerebral infarction were divided into control group(56 cases)and observation group(57 cases)according to random numerical table.The control group was treated with conventional neurological protocol in combination with butylphthalein and sodium chloride injection,and the observation group was treated with safflower yellow for injection on the basis of the control group.The therapeutic effect,occurrence of adverse reactions,National Institutes of Health Stroke Scale(NIHSS)score and hemorheology indexes were compared between the two groups.Results After 14 d of treatment,NIHSS score of(4.20±0.44)points in the observation group was lower than that of(6.21±0.57)points in the control group,and the difference was statistically significant(P<0.05).After 14 d of treatment,the plasma viscosity,hematocrit and fibrinogen levels in the observation group were(1.50±0.14)mPa·s,(0.34±0.05)and(3.10±0.25)g/L,which were significantly lower than those of(1.79±0.17)mPa·s,(0.42±0.07)and(3.31±0.28)g/L in the control group,and the differences were statistically significant(P<0.05).The total effective rate of 96.49% in the observation group was higher than that of 85.71% in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Safflower yellow injection in combination with butylphthalein and sodium chloride injection has definite effect in the treatment of acute cerebral infarction,which can promote the improvement of blood rheology,repair nerve function,and has high safety.

关 键 词：急性脑梗死 注射用红花黄色素 丁苯酞氯化钠注射液 神经功能缺损 

分 类 号：R743.3[医药卫生—神经病学与精神病学]