在根管治疗中给予替硝唑溶液联合盐酸米诺环素对牙周牙髓联合病变的治疗价值研究  

Study on therapeutic value of tinidazole solution combined with minocycline hydrochloride in root canal therapy for combined endodontic-periodontal lesions

作　　者：董鹏 DONG Peng(Shenyang Coal General Hospital of Liaoning Health Industry Group,Shenyang 110122,China)

机构地区：[1]辽宁省健康产业集团沈煤总医院,110122

出　　处：《中国现代药物应用》2023年第18期133-135,共3页Chinese Journal of Modern Drug Application

摘　　要：目的研究根管治疗中分别给予替硝唑溶液、盐酸米诺环素对牙周牙髓联合病变患者的治疗价值。方法208例牙周牙髓联合病变患者,采用随机数字表法分为甲组和乙组,各104例。两组患者均实施根管治疗,甲组患者实施替硝唑溶液消毒,乙组患者实施替硝唑溶液联合盐酸米诺环素消毒。比较两组不良反应发生情况及治疗后牙周临床指标(菌斑指数、出血指数、探诊深度、临床附着水平)。结果甲组发生头晕6例(5.77%),肠胃不适4例(3.85%),气味不适15例(14.42%),不良反应发生率为24.04%(25/104);乙组发生头晕1例(0.96%),肠胃不适1例(0.96%),气味不适4例(3.85%),不良反应发生率为5.77%(6/104);乙组不良反应发生率低于甲组,差异有统计学意义(χ^(2)=13.685,P=0.000<0.05)。治疗6周后,甲组菌斑指数为(2.19±0.32),出血指数为(3.31±1.42),探诊深度为(5.61±1.42)mm,临床附着水平为(5.01±1.22)mm;乙组菌斑指数为(1.78±1.23),出血指数为(2.61±1.13),探诊深度为(5.01±2.11)mm,临床附着水平为(4.11±2.12)mm;乙组菌斑指数、出血指数、探诊深度、临床附着水平均低于甲组,差异有统计学意义(P<0.05)。结论在根管治疗中给予替硝唑溶液和盐酸米诺环素对牙周牙髓联合病变有较高治疗价值,能够改善患者的牙周临床指标及不良反应发生情况,值得推广。Objective To study the therapeutic value of tinidazole solution combined with minocycline hydrochloride in root canal therapy for combined endodontic-periodontal lesions.Methods A total of 208 patients with combined endodontic-periodontal lesions were divided into group A and group B according to the random numerical table,with 104 cases in each group.Root canal therapy was performed in both groups.Group A was disinfected with tinidazole solution,group B was disinfected with tinidazole solution and minocycline hydrochloride.The occurrence of adverse reactions and periodontal clinical indexes(plaque index,bleeding index,probing depth,clinical attachment level)were compared between the two groups.Results In group A,dizziness occurred in 6 cases(5.77%),gastrointestinal discomfort in 4 cases(3.85%),odor discomfort in 15 cases(14.42%),and the incidence of adverse reactions was 24.04%(25/104).In group B,dizziness occurred in 1 case(0.96%),gastrointestinal discomfort in 1 case(0.96%),odor discomfort in 4 cases(3.85%),and the incidence of adverse reactions was 5.77%(6/104).The incidence of adverse reactions in group B was lower than that in group A,and the difference was statistically significant(χ^(2)=13.685,P=0.000<0.05).After 6 weeks of treatment,group A had plaque index of(2.19±0.32),bleeding index of(3.31±1.42),probing depth of(5.61±1.42)mm,and the clinical attachment level of(5.01±1.22)mm;group B had plaque index of(1.78±1.23),bleeding index of(2.61±1.13),probing depth of(5.01±2.11)mm,and the clinical attachment level of(4.11±2.12)mm.The plaque index,bleeding index,probing depth and clinical attachment level of group B were lower than those of group A,and the differences were statistically significant(P<0.05).Conclusion Tinidazole solution and minocycline hydrochloride in root canal therapy have high therapeutic value for combined endodontic-periodontal lesions,and can improve the periodontal clinical indexes and adverse reactions of patients,which is worthy of popularization.

关 键 词：根管治疗 替硝唑溶液 盐酸米诺环素 牙周牙髓联合病变 价值 

分 类 号：R781.05[医药卫生—口腔医学]