Hydrogel-mediated drug delivery for treating stroke  

作　　者：Wenyan Yu Enpeng Gong Bingbing Liu Lei Zhou Chengyuan Che Shu Hu Zhenzhong Zhang Junjie Liu Jinjin Shi 

机构地区：[1]School of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001,China [2]Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases,Zhengzhou 450001,China [3]Collaborative Innovation Center of New Drug Research and Safety Evaluation,Zhengzhou 450001,China

出　　处：《Chinese Chemical Letters》2023年第9期65-75,共11页中国化学快报（英文版）

基　　金：funded by the National Natural Science Foundation of China(Nos.82073395 and 319009919);Postdoctoral Science Foundation of China(No.2020TQ0288);Youth Talent Promotion Foundation of Henan Province(No.2021HYTP047)。

摘　　要：Stroke is a common disease and is the major cause of death and disability.It occurs and generates devastating neurological deficits when cerebral blood vessel is blocked(ischemic stroke,IS)or ruptured(hemorrhagic stroke,HS).Hydrogel,being biodegradable and biocompatible,have shown attractive advantages in stroke therapy as a new biomaterial with desirable mechanical properties and tunability of structure,owing to special ability to load different cargoes for multiple treatment strategies,such as pharmacotherapy based on drug-delivery systems and cell therapy including mesenchymal stem cells(MSCs)and neural progenitor cells(NPCs)for improving functional outcomes.However,a comprehensive review of the functional hydrogel for treatment of stroke is still lacking.Therefore,in this work,the main pathological mechanisms of stroke including IS and HS are comprehensively described.The benefits of hydrogel for stroke treatment are also summarized regarding the natural advantages and the delivery advantages.Simultaneously,the application development of hydrogel for treatment of stroke is highlighted.Finally,the unique considerations and challenges in the design and application of hydrogel is discussed for treatment of stroke and clinical application in the future.

关 键 词：Drug delivery Functional hydrogel Stroke therapy Bioactive biomaterials Biological applications 

分 类 号：R743.3[医药卫生—神经病学与精神病学] TQ427.26[医药卫生—临床医学] TQ460.4[化学工程]