Photochemical multicomponent transformation of acceptor-only diazoalkanes by merging their cycloaddition and carbene reactivities  

作　　者：Bao-Gui Cai Guo-Yong Xu Jun Xuan 

机构地区：[1]Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials,College of Chemistry&Chemical Engineering,Anhui University,Hefei 230601,China [2]Key Laboratory of Structure and Functional Regulation of Hybrid Materials,Ministry of Education,Hefei 230601,China [3]Institute of Physical Science and Information Technology,Anhui University,Hefei 230601,China

出　　处：《Chinese Chemical Letters》2023年第9期138-142,共5页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(Nos.21971001 and 21702001);the Natural Science Foundation of Anhui Province(No.1808085MB47),for financial support。

摘　　要：Herein,we report an efficient photochemical method for the synthesis of poly-substituted pyrazoles through a multicomponent reaction of acceptor-only diazoalkanes,alkynes,and solvents(cyclic ethers or nitriles).The key to this success was driven by the photolysis of acceptor-only diazoalkanes to form free carbene species and the fast in situ[3+2]-cycloaddition formation of nucleophilic N–H pyrazole derivatives.This work also serves as an entry to allow future reaction design on the combination of carbene reactivity of diazoalkanes with their other reaction modes.

关 键 词：Photochemical synthesis Multicomponent reaction Diazoalkanes CARBENE PYRAZOLES 

分 类 号：O644.1[理学—物理化学]