Engineering J-aggregates for NIR-induced meso-CF_(3)-BODIPY nanoparticles by activated apoptosis mechanism in photothermal therapy  

作　　者：Chujing Ye Shan Zhang Dongxiang Zhang Yue Shen Zhan Wang Huan Wang Junyi Ren Xin-Dong Jiang Jianjun Du Rong Shang Guiling Wang 

机构地区：[1]Liaoning&Shenyang Key Laboratory of Functional Dye and Pigment,Shenyang University of Chemical Technology,Shenyang 110142,China [2]Department of Cell Biology,China Medical University,Shenyang 110122,China [3]State Key Laboratory of Fine Chemicals,Dalian University of Technology,Dalian 110624,China [4]Department of Chemistry,Graduate School of Science,Hiroshima University,Higashi-Hiroshima 7398526,Japan

出　　处：《Chinese Chemical Letters》2023年第9期188-192,共5页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.22078201,U1908202);Natural Science Foundation of Liaoning(No.2021NLTS1206);Serving Local Project of Education Department of Liaoning Province(No.LZ2020005);Liaoning&Shenyang Key Laboratory of Functional Dye and Pigment(Nos.2021JH13/10200018,21-104-0-23);the Distinguished Professor Project Liaoning Province(No.20183532)。

摘　　要：Forming J-aggregates by organic monomer is a fascinating strategy to urge spectroscopic redshift with respect to that of the monomer.Herein,we designed 1,7-diphenyl-substituted meso–CF_(3)-BDP monomer confirmed by X-ray crystallographic analysis.The low-barrier rotation of the–CF_(3)group in meso–CF_(3)-BDP1 significantly enhances the non-radiative efficiency,and the photothermal conversion efficiency(PCE)of the self-assembled nanoparticles(1-NPs:λ_(abs)=746 nm)by J-aggregates was 82%.1-NPs could effectively block cell cycle progression,inhibit cancer cell proliferation and trigger cell apoptosis under low power laser irradiation(0.2 W/cm^(2)).This study proposes an alternate molecular design platform by J-aggregates to promote PCE through the insertion of rotating segment and trigger the cancer cells apoptosis in photothermal therapy at low power laser density.

关 键 词：NIR dye J-AGGREGATE CF_(3)-BODIPY Photothermal therapy Cell apoptosis 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R730.5[医药卫生—肿瘤]