NHC-gold(Ⅰ)-alkyne complexes induced hepatocellular carcinoma cell death through bioorthogonal activation by palladium complex in living system  

作　　者：Yunlong Lu Yuanhao Liu Zhenlin Liang Xiaoyan Ma Lijuan Liu Zhenfan Wen Iogann Tolbatov Alessandro Marrone Wukun Liu 

机构地区：[1]Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,School of Medicine&Holistic Integrative Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China [2]Institute of Chemical Research of Catalonia(ICIQ),The Barcelona Institute of Science and Technology,Tarragona 43007,Spain [3]Dipartimento di Farmacia,Universitàdegli Studi“G.D’Annunzio”Chieti-Pescara,Via dei Vestini,Chieti 66100,Italy [4]State key Laboratory of Coordination Chemistry,Nanjing University,Nanjing 210023,China

出　　处：《Chinese Chemical Letters》2023年第9期230-234,共5页中国化学快报（英文版）

基　　金：the financial supports of the National Natural Science Foundation of China(Nos.82173684 and 82204181);Nanjing University of Chinese Medicine National Natural Science Foundation of China Counterpart Funding(No.XPT82204181);General Project of Basic Science in Colleges and Universities of Jiangsu Province(No.21KJB350007);Jiangsu Provincial Health Commission(No.Z2021057);the Open Project of Chinese Materia Medica First Class Discipline of Nanjing University of Chinese Medicine(No.2020YLXK010);the Priority Academic Program Development of Jiangsu Higher Education Institutions(Integration of Chinese and Western Medicine);the experimental support from the Experiment Center for Science and Technology,Nanjing University of Chinese Medicine;financially supported by the“Innovative and Entrepreneurial Team”Program of Jiangsu Province(2020)。

摘　　要：Bioorthogonal reactions can take place in biological environments without interfering with biochemical processes.In this study,Pd(PPh_(3))_(2)Cl_(2)was used as a bioorthogonal catalyst to in situ transform the stable N-heterocyclic carbene(NHC)-gold(Ⅰ)-alkyne complex 5 to its active species which can effectively inhibit thioredoxin reductase(TrxR)and exhibit significant anticancer bioactivity in hepatocellular carcinoma(HCC).

关 键 词：Hepatocellular carcinoma N-Heterocyclic carbene Gold complex ALKYNE Bioorthogonal activation 

分 类 号：R735.7[医药卫生—肿瘤]