微创根治性子宫切除术对宫颈癌患者生活质量和炎性因子的影响  

Effect of minimally invasive radical hysterectomy on quality of life and inflammatory factors in patients with cervical cancer

作　　者：卢琴[1] 黄晨雯 汤凤玲 LU Qin;HUANG Chenwen;TANG Fengling(Department of Gynecology,Fujian Provincial Hospital,Fuzhou 350001,Fujian,China;Department of Obstetrics and Gynecology,Gutian County Hospital,Ningde 352200,Fujian,China;Provincial Clinical Medical College,Fujian Medical University,Fuzhou 350000,Fujian,China)

机构地区：[1]福建省立医院妇科,福州350001 [2]古田县医院妇产科,福建宁德352200 [3]福建医科大学省立临床医学院,福州350000

出　　处：《癌症进展》2023年第14期1551-1554,1574,共5页Oncology Progress

摘　　要：目的 探讨微创根治性子宫切除术对宫颈癌患者生活质量和炎性因子的影响。方法 根据手术方式的不同将150例宫颈癌患者分为开腹组(n=68)和微创组(n=82),开腹组患者给予传统开腹手术,微创组患者给予微创根治性子宫切除术。比较两组患者的生活质量[癌症治疗功能评价系统-共性模块(FACT-G)和癌症治疗功能评价系统中的宫颈癌量表(FACT-Cx)]、炎性因子[白细胞介素(IL)-6、IL-8及肿瘤坏死因子-α(TNF-α)]水平、并发症发生情况和预后情况。结果 术后1个月,两组患者的FACT-Cx、FACT-G评分均高于本组术前,微创组患者的FACT-Cx、FACT-G评分均高于开腹组,差异均有统计学意义(P﹤0.05)。术后1天,两组患者IL-6、IL-8、TNF-α水平均高于本组术前,微创组患者IL-6、IL-8、TNF-α水平均低于开腹组,差异均有统计学意义(P﹤0.05);术后3天,两组患者IL-6、IL-8、TNF-α水平均低于本组术后1天,微创组患者IL-6、IL-8、TNF-α水平均低于开腹组,差异均有统计学意义(P﹤0.05)。微创组患者切口感染、切口二期缝合发生率均低于开腹组,差异均有统计学意义(P﹤0.05);微创组患者并发症总发生率为13.41%,明显低于开腹组患者的42.65%,差异有统计学意义(P﹤0.01)。微创组患者的预后不良总发生率为0%,低于开腹组患者的7.35%,差异有统计学意义(P﹤0.05)。结论 与传统开腹手术相比,微创根治性子宫切除术能有效提高宫颈癌患者的生活质量,降低炎性因子水平,且不会增加并发症发生风险。Objective To investigate the effect of minimally invasive radical hysterectomy on quality of life and in-flammatory factors in patients with cervical cancer.Method A total of 150 patients with cervical cancer were divided in-to laparotomy group(n=68)and minimally invasive group(n=82)according to different surgical methods.The patients in the laparotomy group were given traditional laparotomy,and the patients in the minimally invasive group were given min-imally invasive radical hysterectomy.The quality of life[functional assessment of cancer therapy-general(FACT-G),functional assessment of cancer therapy-cervix(FACT-Cx)],inflammatory factors[interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)]levels,complications,and prognosis were compared between the two groups.Result One month after the operation,the FACT-Cx and FACT-G scores in the two groups were higher than those be-fore the operation,and the scores in the minimally invasive group were higher than those in the laparotomy group,and the differences were statistically significant(P<0.05).One day after the operation,the levels of IL-6,IL-8,and TNF-αin the two groups were higher than those before the operation,and the levels of the three indexes in the minimally invasive group were lower than those in the laparotomy group,and the differences were statistically significant(P<0.05).Three days after the operation,the levels of IL-6,IL-8,and TNF-αin the two groups were lower than those one day after the op-eration,and the levels of the three indexes in the minimally invasive group were lower than those in the laparotomy group,and the differences were statistically significant(P<0.05).The incidences of incision infection and secondary inci-sion sutures in the minimally invasive group were lower than those in the laparotomy group,and the differences were sta-tistically significant(P<0.05).The total incidence of complications in the minimally invasive group was 13.41%,which was significantly lower than 42.65%in the laparotomy group,and the dif

关 键 词：宫颈癌 微创根治性子宫切除术 炎性因子 生活质量 

分 类 号：R737.33[医药卫生—肿瘤]