胸腔镜辅助小切口肺切除术对肺癌患者血清趋化因子、炎症因子和生活质量的影响  

Effect of thoracoscopic-assisted small-incision lung resection on serum chemokines,inflammatory factors,and quality of life in lung cancer patients

作　　者：赵冬峰[1] 郑慧禹[1] 常国涛[1] 杨玉伦[1] ZHAO Dongfeng;ZHENG Huiyu;CHANG Guotao;YANG Yulun(Department of Chest Surgery,People’s Hospital of Zhengzhou,Zhengzhou 450000,He’nan,China)

机构地区：[1]郑州人民医院胸外科,郑州450000

出　　处：《癌症进展》2023年第14期1563-1566,1605,共5页Oncology Progress

摘　　要：目的 探讨胸腔镜辅助小切口肺切除术对肺癌患者血清趋化因子、炎症因子和生活质量的影响。方法 采用随机数字表法将80例肺癌患者分为对照组和观察组,每组40例,对照组患者给予传统开胸手术,观察组患者给予胸腔镜辅助小切口肺切除术。比较两组患者的手术相关指标、血清趋化因子[调节激活正常T细胞表达和分泌因子(RANTES)、单核细胞趋化蛋白-1(MCP-1)、干扰素诱导蛋白-10(IP-10)]、炎症因子[白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、前列腺素E_(2)(PGE_(2))]、干扰素调节因子2(IRF2)水平和生活质量[健康调查简表(SF-36)]。结果 观察组患者手术时间、术后置管时间、下床活动时间、术后住院时间均明显短于对照组,术中出血量明显少于对照组,差异均有统计学意义(P﹤0.01)。术后3天,两组患者RANTES、MCP-1、IP-10、IL-6、IL-8、PGE_(2)水平均高于本组术前,观察组患者RANTES、MCP-1、IP-10、IL-6、IL-8、PGE_(2)水平均低于对照组,差异均有统计学意义(P﹤0.05);术后5天,两组患者RANTES、MCP-1、IP-10、IL-6、IL-8、PGE_(2)水平均低于本组术后3天,观察组患者RANTES、MCP-1、IP-10、IL-6、IL-8、PGE_(2)水平均低于对照组,差异均有统计学意义(P﹤0.05)。术后3、5天,两组患者IFR2水平均高于本组术前,差异均有统计学意义(P﹤0.05)。术后6个月,两组患者SF-36量表各维度评分均高于本组术前,观察组患者SF-36量表各维度评分均高于对照组,差异均有统计学意义(P﹤0.05)。结论 胸腔镜辅助小切口肺切除术可显著减少肺癌患者的术中出血量,缩短手术时间,并能更好地控制炎症因子和趋化因子水平,提高生活质量。Objective To investigate the effect of thoracoscopic-assisted small-incision lung resection on serum che-mokines,inflammatory factors and quality of life in lung cancer patients.Method A total of 80 lung cancer patients were divided into control group(n=40,received traditional open surgery)and observation group(n=40,received thoraco-scopicassisted small-incision lung resection)according to the random number table method.The surgical related indica-tors,serum chemokines[regulated upon activation normal T cell expressed and secreted(RANTES),monocyte chemotax-is protein-1(MCP-1),interferon-induced protein-10(IP-10)],inflammatory factors[interleukin-6(IL-6),interleukin-8(IL 8),prostaglandin E2(PGE2)],interferon regulatory factor 2(IRF2),and quality of life[the MOS 36-item short form health survey(SF-36)]were compared between the two groups.Result The operation time,postoperative catheterization time,postoperative ambulation time,and postoperative hospital stay in the observation group were significantly shorter than those in the control group,the intraoperative bleeding was less than that in the control group(P<0.01).On the 3rd day af-ter surgery,the levels of RANTES,MCP-1,IP-10,IL-6,IL-8,and PGE2 in both groups were higher than those before sur-gery,the levels of RANTES,MCP-1,IP-10,IL-6,IL-8,and PGE2 in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).On the 5th day after surgery,the levels of RANTES,MCP-1,IP-10,IL-6,IL-8,and PGE2 in both groups were lower than those on the 3rd day after surgery,the levels of RAN-TES,MCP-1,IP-10,IL-6,IL-8,and PGE2 in the observation group were lower than those in the control group,and the dif-ferences were statistically significant(P<0.05).On the 3rd and 5th day after surgery,the IFR2 levels in both groups were higher than those before surgery,and the differences were statistically significant(P<0.05).Six months after surgery,the scores of each dimension of the SF-36 scale in both groups were higher than those be

关 键 词：肺癌 胸腔镜辅助小切口肺切除术 趋化因子 干扰素调节因子2 

分 类 号：R734.2[医药卫生—肿瘤]