显微镜下全切术对脑胶质瘤患者认知功能、神经功能及生活能力的影响  

Effect of microscopic total resection on cognitive function,neurological function,and living ability of patients with glioma

作　　者：赵舒杨 雷艳杰 马世杰[1] 高明[1] ZHAO Shuyang;LEI Yanjie;MAShijie;GAO Ming(Department of Neurosurgery,Zhoukou Central Hospital,Zhoukou 466000,He’nan,China;Department of Pathology,Zhoukou Central Hospital,Zhoukou 466000,He’nan,China)

机构地区：[1]周口市中心医院神经外科,河南周口466000 [2]周口市中心医院病理科,河南周口466000

出　　处：《癌症进展》2023年第14期1598-1601,共4页Oncology Progress

摘　　要：目的 探讨显微镜下全切术对脑胶质瘤患者认知功能、神经功能及生活能力的影响。方法 根据手术方式的不同将100例脑胶质瘤患者分为传统切除术组(n=50,传统开颅切除术)和显微全切术组(n=50,显微镜下全切术)。比较两组患者的手术相关指标、认知功能[简易精神状态检查量表(MMSE)]、神经功能[美国国立卫生研究院卒中量表(NIHSS)]、生活能力[日常生活能力量表(ADL)]及生存情况。结果 显微全切术组患者的手术时间和术后下床活动时间均明显短于传统切除术组,术中出血量明显少于传统切除术组,手术切口长度明显短于传统切除术组,差异均有统计学意义(P﹤0.01)。手术后,两组患者语言能力、回忆能力、注意力、计算能力、定向力评分均高于本组手术前,显微全切术组患者语言能力、回忆能力、注意力、计算能力、定向力评分均高于传统切除术组,差异均有统计学意义(P﹤0.05)。手术后,两组患者NIHSS评分均低于本组手术前,ADL评分均高于本组手术前,显微全切术组患者NIHSS评分低于传统切除术组,ADL评分高于传统切除术组,差异均有统计学意义(P﹤0.05)。两组患者的1年生存率比较,差异无统计学意义(P﹥0.05)。结论 显微镜下全切术治疗脑胶质瘤的疗效确切,可有效改善患者的认知功能和神经功能,提高患者的日常生活能力,值得临床推广应用。Objective To investigate the effect of microscopic total resection on cognitive function,neurological func-tion,and living ability of patients with glioma.Method A total of 100 patients with glioma were divided into traditional resection group(n=50,traditional craniotomy)and microscopic total resection group(n=50,microscopic total resection)according to different surgical methods.The surgery-related indicators,cognitive function[mini-mental state examination(MMSE)],neurological function[National Institutes of Health stroke scale(NIHSS)],living ability[activity of daily liv-ing scale(ADL)]and survival were compared between the two groups.Result The operation time and postoperative am-bulation time of the microscopic total resection group were significantly shorter,the blood loss during the operation was significantly less,and the length of surgical incision was significantly shorter than those of the traditional resection group,and the differences were statistically significant(P<0.01).After the operation,the language ability,memory ability,atten-tion,calculation ability,and orientation of the two groups were higher than those before the operation,and the above scores of microscopic total resection group were higher than those of the traditional resection group,and the differences were statistically significant(P<0.05).After the operation,the NIHSS scores of the two groups were lower than those be-fore the operation,the ADL scores were higher than those before the operation,and the NIHSS score of the microscopic total resection group was lower than that of the traditional resection group,and the ADL score was higher than that of the traditional resection group,and the differences were statistically significant(P<0.05).There was no significant difference in the one-year survival rate between the two groups(P>0.05).Conclusion The curative effect of microscopic total re-section in treating glioma is remarkable,the method could effectively improve the cognitive function and neurological function of patients,and improv

关 键 词：脑胶质瘤 显微镜下全切术 认知功能 神经功能 生活能力 

分 类 号：R739.41[医药卫生—肿瘤]