p53和B细胞淋巴瘤/白血病-2蛋白在弥漫性大B细胞淋巴瘤中的表达及与预后的关系  

Expression of p53 and B-cell lymphoma/leukemia-2 protein in diffuse large Bcell lymphoma and their relationship with prognosis

作　　者：董娜[1] 王晓娟[1] 刘世琼[2] DONG Na;WANG Xiaojuan;LIU Shiqiong(Department of Pathology,School of Clinical Medicine,He’nan University of Science and Technology/the First Affiliated Hospital of He’nan University of Science and Technology,Luoyang 471000,He’nan,China;Department of Trauma Surgery,School of Clinical Medicine,He’nan University of Science and Technology/the First Affiliated Hospital of He’nan University of Science and Technology,Luoyang 471000,He’nan,China)

机构地区：[1]河南科技大学临床医学院/河南科技大学第一附属医院病理科,河南洛阳471000 [2]河南科技大学临床医学院/河南科技大学第一附属医院创伤外科,河南洛阳471000

出　　处：《癌症进展》2023年第15期1687-1690,共4页Oncology Progress

摘　　要：目的 探讨p53和B细胞淋巴瘤/白血病-2(Bcl-2)蛋白在弥漫性大B细胞淋巴瘤(DLBCL)中的表达及与预后的关系。方法 对72例DLBCL患者进行p53和Bcl-2蛋白检测,并分析p53和Bcl-2蛋白表达情况与DLBCL患者临床特征及预后的关系。结果 DLBCL组织中Bcl-2阳性表达率为47.22%(34/72),p53阳性表达率为52.78%(38/72)。非生发中心(non-GCB)型、有骨髓侵犯、临床分期为Ⅲ~Ⅳ期DLBCL患者的DLBCL组织中Bcl-2阳性表达率均明显高于生发中心(GCB)型、无骨髓侵犯及临床分期为Ⅰ~Ⅱ期患者,差异均有统计学意义(P﹤0.01)。non-GCB型、乳酸脱氢酶(LDH)水平升高、临床分期为Ⅲ~Ⅳ期DLBCL患者DLBCL组织中p53阳性表达率均明显高于GCB型、LDH正常及临床分期为Ⅰ~Ⅱ期患者,差异均有统计学意义(P﹤0.01)。不同Bcl-2、p53表达情况的DLBCL患者总生存率(OS)和无进展生存率(PFS)比较,差异均有统计学意义(P﹤0.01)。Cox回归分析结果显示,p53阳性表达为DLBCL患者OS、PFS的危险因素(P﹤0.05)。结论 p53和Bcl-2蛋白与DLBCL的分型均存在一定关联,根据p53和Bcl-2蛋白的表达情况,可预测DLBCL的分型,且p53作为DLBCL预后的危险因素,根据其表达情况可提前评估DLBCL患者的预后情况。Objective To investigate the expression of p53 and B-cell lymphoma/leukemia-2(Bcl-2)protein in dif-fuse large B-cell lymphoma(DLBCL)and their relationship with prognosis.Method The p53 and Bcl-2 proteins were detected in 72 patients with DLBCL,and the relationship between the expression of p53,Bcl-2 proteins and clinical fea-tures,prognosis of DLBCL patients were also analyzed.Result The positive expression rate of Bcl-2 in DLBCL tissues was 47.22%(34/72),and the positive expression rate of p53 was 52.78%(38/72).The positive expression rate of Bcl-2 in DLBCL tissues of DLBCL patients of non-germinal center(non-GCB)type,bone marrow invasion,and clinical stage III IV were significantly higher than those of germinal center(GCB)type,no bone marrow invasion,clinical stage I-II pa-tients,and the differences were statistically significant(P<0.01).The positive expression rate of p53 in DLBCL tissues of DLBCL patients of non-GCB type,elevated lactate dehydrogenase(LDH)level,and clinical stage III-IV were significant-ly higher than those of GCB type,normal LDH,and clinical stage I-II patients,and the differences were statistically sig-nificant(P<0.01).There were statistically significant differences in the overall survival(OS)and progression-free surviv-al(PFS)of DLBCL patients with different Bcl-2 and p53 expressions(P<0.01).The results of Cox regression analysis showed that the positive expression of p53 was the risk factor for OS and PFS in DLBCL patients(P<0.05).Conclusion Both p53 and Bcl-2 proteins are related to the type of DLBCL.According to the expression of p53 and Bcl-2 protein,the type of DLBCL would be predicted.Moreover,p53 is the risk factor for the prognosis of DLBCL,and the prognosis of DLBCL patients could be assessed in advance according to its expression.

关 键 词：弥漫性大B细胞淋巴瘤 P53 B细胞淋巴瘤/白血病-2 预后 

分 类 号：R733.4[医药卫生—肿瘤]