光遗传学作为肿瘤治疗的新策略  

Optogenetics as a new strategy for tumor therapy

作　　者：魏素云 牟伟伟 刘永军 张娜 WEI Suyun;MU Weiwei;LIU Yongjun;ZHANG Na(Key Laboratory of Chemical Biology Ministry of Education,School of Pharmaceutical Sciences,Shandong University,Ji’nan 250012,China)

机构地区：[1]山东大学药学院,天然产物化学生物学教育部重点实验室,济南250012

出　　处：《生命的化学》2023年第8期1179-1185,共7页Chemistry of Life

基　　金：国家自然科学基金项目(82173756);国家自然科学基金青年基金(82204295);山东省优秀青年基金项目(ZR2022YQ76)。

摘　　要：光遗传学技术利用光敏元件对光的响应实现对目标的定时和定位调控,具有无创、可控和响应快速等优势。利用基因编码蛋白质系统,光遗传学能够对肿瘤发生和进展中的关键蛋白质进行光控调节,从而为肿瘤治疗提供了一种新策略。基于此,本文介绍了光遗传学技术的基本元件与应用形式,综述了近年来光遗传学技术在肿瘤治疗领域的研究进展,以期为光遗传学技术的应用以及向临床实践的转化探索新思路。Optogenetics technology uses the response of photosensitive elements to light to realize the target timing and positioning regulation,which has the advantages of non-invasive,controllable,and fast response.Using the gene coding system,optogenetics can photoregulate the key proteins in the occurrence and progression of tumors,thus providing a new strategy for tumor therapy.Based on this,this paper introduces the basic components and application forms of optogenetics technology,and reviews the research progress of optogenetics technology in the field of tumor therapy in recent years,in order to explore new ideas for the application of optogenetics technology and its transformation into clinical practice.

关 键 词：光遗传学 光敏元件 肿瘤治疗 

分 类 号：R730.5[医药卫生—肿瘤]