甲基化酶样14在肿瘤发生发展中的作用  

The roles of methylase like 14 in tumorigenesis and development

作　　者：邓成伍 马东江 张栋岩 魏相相 高远飞 王琛[1,2] DENG Chengwu;MA Dongjiang;ZHANG Dongyan;WEI Xiangxiang;GAO Yuanfei;WANG Chen(The Second Clinical Medical College of Lanzhou University,Lanzhou 730000,China;Department of General Surgery,Lanzhou University Second Hospital,Lanzhou 730000,China)

机构地区：[1]兰州大学第二临床医学院,兰州730000 [2]兰州大学第二医院普外科,兰州730000

出　　处：《生命的化学》2023年第8期1186-1193,共8页Chemistry of Life

基　　金：甘肃省科技重大专项计划项目(19ZD2WA001);兰州大学第二医院“萃英科技创新”计划(CY2021-MS-A17);甘肃省自然科学基金项目(23JRRA0979);甘肃省青年科技基金项目(23JRRA1008)。

摘　　要：N6-甲基腺嘌呤(N6-methyladenine,m6A)是真核生物中最丰富的RNA化学修饰,在生长发育和疾病发展中扮演重要角色。作为m 6 A甲基转移酶复合物重要组成部分,甲基化酶样14(methyltransferase like 14,METTL14)通过介导m6A修饰不同分子机制和信号通路中的靶标来参与肿瘤的发生发展过程。本文基于m6A修饰过程,将METTL14在肿瘤发生发展中的作用进行综述,探讨METTL14与肿瘤干细胞增殖更新、肿瘤发生、肿瘤表型转化、肿瘤上皮细胞-间充质转化、自噬、免疫及化学治疗之间的作用机制,并介绍了METTL14在肿瘤中表达和预后的关系,旨在为METTL14在恶性肿瘤的基础研究和临床诊疗提供理论支持。N6-methyladenine(m6A)is the most abundant RNA chemical modification in eukaryotes,which plays an important role in growth and disease development.Methyltransferase like 14(METTL14),as an important component of m6A methyltransferase complex,mediates m6A to modify targets in different molecular mechanisms and signaling pathways to participate in the occurrence and development of tumors.Based on the m6A modification process,this paper reviews the role of METTL14 in tumorigenesis and development,and discusses the mechanism of METTL14 and tumor stem cell proliferation and renewal,tumorigenesis,tumor phenotypic transformation,tumor epithelial-mesenchymal transition,autophagy,immunity and chemotherapy.The relationship between the expression of METTL14 in tumors and prognosis was also introduced,aiming to provide theoretical support for the basic research and clinical diagnosis and treatment of METTL14 in malignant tumors.

关 键 词：甲基化酶样14 N6-甲基腺嘌呤 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]