锶的成骨机制及富锶食品的研发现状  

Osteogenic Mechanism of Action of Strontium and Research andDevelopment Status of Strontium-rich Foods

作　　者：席雪瑶 高亚男[1] 王加启[1] 郑楠[1] XI Xueyao;GAO Yanan;WANG Jiaqi;ZHENG Nan(Institute of Animal Sciences of Chinese Academy of Agricultural Sciences,Key Laboratory of Quality and Safety Control of Milk and Dairy Products,Laboratory of Milk Product Quality and Safety Risk Assessment,the Ministry of Agriculture and Rural Affairs,Beijing 100193,China)

机构地区：[1]中国农业科学院北京畜牧兽医研究所,农业农村部奶及奶制品质量安全控制重点实验室,农业农村部奶产品质量安全风险评估实验室,北京100193

出　　处：《现代食品科技》2023年第9期380-392,共13页Modern Food Science and Technology

基　　金：财政部和农业农村部国家现代农业产业技术体系资助(CARS36);中国农业科学院科技创新工程(ASTIP-IAS12)。

摘　　要：锶是人体必需的一种微量元素,广泛分布于人体组织内,骨骼是其最大的“储存库”,约99%的锶都以离子形式存在于其中。锶可从多方面对骨骼健康产生广泛而深远的影响,在临床上药物雷奈酸锶可以通过影响骨代谢从而为骨骼健康保驾护航已成为一种共识,但其是一种人工合成化学品,安全性远不如天然锶盐类,故而研发富锶食品从而使人们通过日常膳食途径就可以达到呵护骨健康的目的正在逐渐成为研究热点。该研究就常见骨科疾病的发病类型、锶对骨代谢的作用机制及食品型锶制品的现状及开发进行综述,重点探讨了锶可同时调节成骨细胞和破骨细胞的双重成骨机制以及富锶食品现状,为锶在骨科疾病上的应用及富锶食品更好的开发提供理论依据。Strontium is an essential trace element widely distributed in human tissues,with bone being its largest"reservoir",in which approximately 99%of strontium is present in the ionic form.Strontium has a considerable impact on bone health,and hence there is wide research consensus that the clinical drug strontium ranelate can protect bone health by influencing bone metabolism.However,as it is a synthetic chemical that is less safe than natural strontium salts,the development of strontium-rich foods which will aid individuals to care for their bone health through their daily dietary routine,has garnered increasing research attention.This paper reviews the types of common orthopedic diseases,the mechanism of action of strontium on bone metabolism,and the current status and development of food-based strontium products,focusing on the dual osteogenic mechanism of strontium regulating both osteoblasts and osteoclasts and the current situation of strontium-rich foods.The findings of this study providea theoretical basis for the application of strontium in orthopedic diseases and the improved development of strontium-rich foods.

关 键 词：锶 骨科疾病 成骨机制 双重作用 富锶食品 

分 类 号：TS201.4[轻工技术与工程—食品科学]