长期小剂量米非司酮治疗子宫肌瘤的临床效果分析  

Analysis of clinical effect of long-term low-dose mifepristone in the treatment of uterine fibroids

作　　者：幸琼 陈建荣 XING Qiong;CHEN Jian-rong(Jiangxi Gao'an people's Hospital,Gao'an 330800,China)

机构地区：[1]江西省高安市人民医院,330800

出　　处：《中国实用医药》2023年第18期121-124,共4页China Practical Medicine

摘　　要：目的探讨子宫肌瘤患者应用长期小剂量米非司酮治疗的临床效果。方法84例子宫肌瘤患者,按照随机摸球法分为A组与B组,每组42例。A组给予长期小剂量米非司酮治疗,B组给予常规剂量米非司酮治疗。对比两组临床疗效及血清性激素[雌二醇(E2)、孕酮(P)、促黄体生成素(LH)、促卵泡刺激素(FSH)]水平、子宫体积、肌瘤体积、不良反应发生率。结果A组治疗总有效率为95.24%(40/42),高于B组的71.43%(30/42),差异具有统计学意义(P<0.05)。治疗6个月后,两组P、E2、FSH、LH水平均低于本组治疗前,且A组P(1.37±0.45)nmol/L、E2(387.53±26.32)pmol/L、FSH(15.07±1.15)U/L、LH(6.31±1.17)U/L低于B组的(1.85±0.51)nmol/L、(436.27±29.71)pmol/L、(19.55±2.27)U/L、(9.68±1.52)U/L,差异具有统计学意义(P<0.05)。治疗6个月后,两组子宫体积、肌瘤体积均小于本组治疗前,差异具有统计学意义(P<0.05)。A组不良反应发生率9.52%(4/42)明显低于B组的26.19%(11/42),差异具有统计学意义(P<0.05)。结论长期小剂量米非司酮在子宫肌瘤患者中应用可促进患者血清性激素水平改善,缩小子宫体积、肌瘤体积,有效提高临床疗效,且不良反应发生率较低,值得临床推广应用。Objective To discuss the clinical effect of long-term low-dose mifepristone in the treatment of uterine fibroids.Methods A total of 84 patients with uterine fibroids were randomly divided into group A and group B,with 42 cases in each group.Group A was treated with long-term low-dose mifepristone,and group B was treated with conventional dose of mifepristone.Both groups were compared in terms of clinical efficacy,levels of serum sex hormones[estradiol(E2),progesterone(P),luteinizing hormone(LH),follicle-stimulating hormone(FSH)],uterine volume,fibroid volume,and incidence of adverse reactions.Results The total effective rate of group A was 95.24%(40/42),which was higher than that of 71.43%(30/42)of group B,and the difference was statistically significant(P<0.05).After 6 months of treatment,the levels of P,E2,FSH and LH in both groups were lower than those before treatment in this group;group A had P of(1.37±0.45)nmol/L,E2 of(387.53±26.32)pmol/L,FSH of(15.07±1.15)U/L and LH of(6.31±1.17)U/L,which were lower than those of(1.85±0.51)nmol/L,(436.27±29.71)pmol/L,(19.55±2.27)U/L and(9.68±1.52)U/L in group B;the differences were statistically significant(P<0.05).After 6 months of treatment,the uterine volume and fibroid volume of the two groups were lower than those of this group before treatment,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in group A was 9.52%(4/42),which was significantly lower than that of 26.19%(11/42)in group B,and the difference was statistically significant(P<0.05).Conclusion The application of long-term low-dose mifepristone in patients with uterine fibroids can promote the improvement of serum sex hormone levels,reduce uterine and fibroid volume,effectively improve the clinical efficacy,and the incidence of adverse reactions is relatively low,which is worthy of clinical promotion and application.

关 键 词：小剂量 米非司酮 子宫肌瘤 血清性激素水平 临床疗效 

分 类 号：R737.33[医药卫生—肿瘤]