细针穿刺细胞学诊断甲状腺髓样癌4例报告  

Diagnosis of medullary thyroid carcinoma by fine-needle aspiration cytology:a report of 4 cases

作　　者：钟雪君 王艳芬 ZHONG Xuejun;WANG Yanfen(Pathology Department,the Sixth Affiliated Hospital of Guangzhou Medical University,Qingyuan People’s Hospital,Guangdong,Qingyuan 511500,China)

机构地区：[1]广州医科大学附属第六医院、清远市人民医院病理科,广东清远511500

出　　处：《中国医药科学》2023年第18期191-194,共4页China Medicine And Pharmacy

摘　　要：目的探讨甲状腺髓样癌(MTC)的细胞学特点及临床病理特征,以提高细针穿刺细胞学(FNAC)诊断MTC的准确性。方法回顾术后病理诊断为MTC的4例甲状腺细针穿刺病例,收集其临床病理资料,比较分析细胞学、组织病理形态及免疫组化结果。结果4例初次细胞学诊断均未直接确诊为MTC,细胞学形态均有相似之处,浆细胞样细胞、“胡椒盐”样核及怪异大细胞等是MTC较常见的细胞学特点,但也有其他不同细胞形态。结论FNAC能识别约50%的MTC病变,是目前术前诊断MTC的首选方法。优质的细胞涂片及蜡块制备并仔细辨认特征性的细胞学形态有助于提高FNAC的准确性。Objective To explore the cytological and clinicopathological characteristics of medullary thyroid carcinoma(MTC),in order to improve the accuracy of fine-needle aspiration cytology(FNAC)in diagnosing MTC.Methods A total of 4 cases with thyroid fine-needle aspiration diagnosed as MTC after surgery were reviewed,relevant clinicopathological data were collected,and cytological,histopathological,and immunohistochemical results were compared and analyzed.Results The initial cytological diagnosis of all 4 cases was not directly confirmed as MTC,and the cytological morphology was similar.Plasmacytoid cells,"salt-and-pepper"-like nuclei,and strange large cells are common cytological characteristics of MTC,but there are also other cell forms.Conclusion FNAC can identify approximately 50%of MTC lesions and is currently the preferred method for preoperative diagnosis of MTC.High-quality cell smear and wax preparation,as well as careful identification of characteristic cytological morphology,will help improve the accuracy of FNAC.

关 键 词：甲状腺髓样癌 细针穿刺细胞学 细胞学特点 临床病理特征 

分 类 号：R736.1[医药卫生—肿瘤]