DNA 异常甲基化在口腔鳞癌中的研究进展  

Advances in Research on Aberrant DNA Methylation in Oral SquamousCell Carcinoma

作　　者：许益敏 崔丹 卢志远 卢杨 周梦缘 肖灿[1,3] XU Yimin;CUI Dan;LU Zhiyuan;LU Yang;ZHOU Mengyuan;XIAO Can(Department of Stomatology,Suzhou Univercity Affiliated First Hospital,Suzhou,Jiangsu,215000,China;Department of Stomatology,Suzhou Huaxia Stomatological Hospital,Suzhou,Jiangsu,215000,China;School of Medicine,Suzhou Univercity,Suzhou,Jiangsu,215000,China)

机构地区：[1]苏州大学附属第一医院口腔科,江苏省苏州市215000 [2]苏州市华夏口腔医院口腔科,江苏省苏州市215000 [3]苏州大学医学院,江苏省苏州市215000

出　　处：《医学分子生物学杂志》2023年第5期455-461,466,共8页Journal of Medical Molecular Biology

基　　金：苏州大学附属第一医院口腔科临床试验机构能力提升项目(No.SLT202009)。

摘　　要：口腔鳞癌是一种常见的头颈部恶性肿瘤,其发生和发展与基因的异常表达有关。DNA异常甲基化是一种影响基因表达的机制,已经被证实在口腔鳞癌的发生和发展中起着重要作用。综述主要对DNA甲基化在口腔鳞癌中的研究进展及检测技术手段进行阐述,包括样本的类型、与口腔鳞癌相关的基因甲基化水平、生物学功能及其在肿瘤进展中的临床解读。未来的研究将继续深入探究DNA异常甲基化与口腔鳞癌的发生、发展、治疗和预后之间的关系,有助于寻找更有效的治疗策略和预后评估方法。Oral squamous cell carcinoma(OSCC)is a common malignant tumor of head and neck,whose development is related to the abnormal gene expression.Aberrant DNA methylation is a mechanism that affects gene expression and has been proven to play an important role in OSCC initiation and development.This review mainly discusses the research progress and detection techniques of DNA methylation in OSCC,including sample types,methylation levels of genes related to OSCC,their biological functions and clinical interpretations in tumor progression.The future research will continue to explore the relationship between abnormal DNA methylation and OSCC initiation,development,treatment and prognosis,in order to find more effective treatment strategies and prognosis assessment methods.

关 键 词：DNA甲基化 口腔鳞癌 诊断 发生发展和预后 

分 类 号：R782[医药卫生—口腔医学]