迷走神经及其胆碱能受体在炎症性肠病中的研究进展  

Progress of Research on Vagus Nerve and its Cholinergic Receptors in Inflammatory Bowel Disease

作　　者：翟进阳 陈颖伟[1,2] ZHAI Jinyang;CHEN Yingwei(Department of Gastroenterology,Xinhua Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai,200092;Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition,Shanghai)

机构地区：[1]上海交通大学医学院附属新华医院消化内科,200092 [2]上海市小儿消化与营养重点实验室

出　　处：《胃肠病学》2022年第10期628-631,共4页Chinese Journal of Gastroenterology

基　　金：国家自然科学基金(81974061)。

摘　　要：炎症性肠病(IBD)是一种病因不明的肠道慢性、复发性、非特异性炎症疾病。迷走神经及其胆碱能受体,包括烟碱乙酰胆碱受体和毒蕈碱乙酰胆碱受体,参与抑制肠道炎症、调节肠上皮屏障通透性、调节肠道干细胞增殖与分化,在IBD的发病机制中起重要作用。肠道微生态失调与迷走神经结构重塑、信号转导改变等是否有关联仍需探索,以迷走神经及其胆碱能受体为靶点的治疗策略(包括迷走神经刺激和尼古丁制剂)仍在研究中。本文就迷走神经及其胆碱能受体在IBD中的研究进展作一综述。Inflammatory bowel disease(IBD)is a chronic,recurrent,non-specific inflammatory disease with unknown etiology.The vagus nerve and its cholinergic receptors,including nicotinic acetylcholine receptor and muscarinic acetylcholine receptor,are involved in inhibiting intestinal inflammation,regulating intestinal epithelial barrier permeability,regulating intestinal stem cell proliferation and differentiation,and play an important role in the pathogenesis of IBD.Whether there is a correlation between intestinal microbiota dysbiosis and vagus nerve structure remodeling,signal transduction changing remains to be explored.The therapeutic strategies targeting the vagus nerve and its cholinergic receptors including vagus nerve stimulation and nicotine are still being studied.This article reviewed the progress of research on vagus nerve and its cholinergic receptors in IBD.

关 键 词：炎症性肠病 迷走神经 受体 胆碱能 迷走神经刺激 尼古丁 

分 类 号：R574[医药卫生—消化系统]