清除脑内衰老细胞治疗阿尔茨海默病的研究进展  

Review of theoretic methods for Alzheimer’s disease by removing the senescent brain cells

作　　者：边宇航 张凌 王丹 陈靖[1] 梁喜才 王威丽 弓彦[1] 吴运谱 宁天一[1] 王春田[1] BIAN Yu-hang;ZHANG Ling;WANG Dan;CHEN Jing;LIANG Xi-cai;WANG Wei-li;GONG Yan;WU Yun-pu;NING Tian-yi;WANG Chun-tian(Liaoning University of Traditional Chinese Medicine,Shenyang 110847;Shenyang Institute for Fool and Drug Control,Shenyang 110000;Liaoning Inspection,Examination&Certification Centre,Shenyang 110032)

机构地区：[1]辽宁中医药大学,沈阳110847 [2]沈阳市食品药品检验所,沈阳110000 [3]辽宁省药品检验检测院,沈阳110032

出　　处：《中南药学》2023年第9期2413-2418,共6页Central South Pharmacy

基　　金：2022国家级大学生创新创业训练计划项目(No.202210162011);2022辽宁省级大学生创新创业训练计划项目(No.S202210162005)。

摘　　要：阿尔茨海默病(AD)是一种与年龄和衰老相关的进行性认知障碍,发病隐匿且不可逆,已成为全球重大健康和社会经济问题。细胞衰老是影响AD进程的重要因素,而随着研究的不断深入,Senolytic和Senomorphic等疗法可通过清除衰老细胞(SCs)达到治疗AD的目的。故笔者对衰老诱发AD的机制及清除SCs治疗AD的研究进展进行阐述,为AD防治及SCs清除剂的研发提供新的思路。Alzheimer’s disease(AD)is a degenerative cognitive condition associated with aging and senescence disorder with an insidious and irreversible onset which has become a significant global health and socio-economic issue.The progression of AD is significantly influenced by cellular senescence.As research continues,Senolytic and Senomorphic therapies for AD work well by clearing the senescent cells.Therefore,the author elaborated on the mechanism of senescence-induced AD and removal of the senescent cells for AD,to provide new insight for preventing and treating AD.

关 键 词：阿尔茨海默病 衰老细胞 衰老细胞清除剂 

分 类 号：R739.41[医药卫生—肿瘤]