第二周期应用维布妥昔单抗致过敏性休克病例报告一例  

A case report of anaphylactic shock induced by the second cycle application of Brentuximab Vedotin

作　　者：王卫卫[1] 于志良 徐鹏飞 WANG Wei-wei;YU Zhi-liang;XU Peng-fei(Weihai Central Hospital Affiliated to Qingdao University,Weihai 264400,China)

机构地区：[1]青岛大学附属威海市中心医院,山东威海264400

出　　处：《医师在线》2023年第9期61-63,共3页Journal of Doctors Online

摘　　要：报告1例48岁女性霍奇金淋巴瘤患者接受维布妥昔单抗和苯达莫司汀联合治疗,静脉滴注注射用维布妥昔单抗后约14 min,患者突感喘憋、颜面及周身痒感潮红、周身散在荨麻疹、双眼睑水肿、喉部喘鸣音、双肺呼吸音粗并可闻及少量湿啰音、大汗淋漓、面色苍白、口唇发绀,心率111次/min,呼吸24次/min,血压57/30 mmHg,考虑为维布妥昔单抗致过敏性休克。立即予鼻导管吸氧及心电监测,地塞米松20 mg静推抗过敏抗水肿抗休克、二羟丙茶碱解痉改善支气管痉挛、葡萄糖钙及苯海拉明抗过敏。27 min后患者血压回升至90/45 mmHg,喘憋减轻,皮肤瘙痒缓解。继续给予心电监测、补液治疗,严密观察病情变化。A 48-year-old women with Hodgkin’s lymphoma received a combined treatment of Brentuximab Vedotin and Bendamustine.About 14 minutes after intravenous drip of Brentuximab Vedotin for injection,the patient had sudden dyspnea,facial and body itching,scattered urticaria,eyelid edema,laryngeal wheezing,thick and a small amount of wet rales in the lungs,sweating,pale complexion,cyanosis of lips.Her heart rate was 111 beats per minute,breathing rate was 24 breaths per minute,and blood pressure was 57/30 mmHg,considered as anaphylactic shock caused by Brentuximab Vedotin.Nasal catheter oxygen inhalation and ECG monitoring were performed immediately.Dexamethasone 20 mg was given intravenously for anti-allergy,anti-edema and anti-shock.Diprophylline antispasmodic was used to improve bronchospasm.Calcium glucose and diphenhydramine were used for anti-allergy.27 minutes later,the blood pressure of the patient returned to 90/45 mmHg,the dyspnea and the skin itching were relieved.Continue to give ECG monitoring,fluid infusion,and closely observe the changes in the condition.

关 键 词：维布妥昔单抗 过敏性反应 药疹 

分 类 号：R73[医药卫生—肿瘤]