诺美孕酮醋酸酯和香草酸的共晶研究  

Study on co-crystal of nomegestrol acetate and vanillic acid

作　　者：顾嘉 陈晓锋 宁丽峰 GU Jia;CHEN xiaofeng;NING Lifeng(The Comprehensive Service Center of Tianjin Commission of Health,Tianjin,300131;National Research Institute for Family Planning)

机构地区：[1]天津市卫生健康委员会综合服务中心,300131 [2]国家卫生健康委科学技术研究所

出　　处：《中国计划生育学杂志》2023年第9期2022-2024,I0001,共4页Chinese Journal of Family Planning

基　　金：2021年中央国家机关公益性科技创新基金重点项目基金编号(2021GJZ06)。

摘　　要：目的:对诺美孕酮醋酸酯共晶的结构和稳定性进行系统研究。方法:应用研磨法制备诺美孕酮醋酸酯-香草酸共晶,并采用粉末X射线衍射(PXRD)、热重分析法(TG)、差示扫描量热分析法(DSC)、红外光谱法(IR)等晶型结构确证方法对共晶结构进行表征,并进一步研究了诺美孕酮醋酸酯共晶的稳定性。结果:结构表征表明成功制备得到了诺美孕酮醋酸酯-香草酸共晶,稳定性研究表明诺美孕酮醋酸酯-香草酸共晶具有良好的稳定性。结论:诺美孕酮醋酸酯-香草酸共晶具有良好的物理稳定性,是潜在的药用固体形态。Objective:To investigate the structure and the stability of nomegestrol acetate co-crystal systematically.Methods:The nomegestrol acetate-vanillic acid co-crystal was designed and synthesized in the laboratory,and the obtained structure was characterized by powder X-ray diffraction(PXRD),thermal gravimetric analysis(TG),differential scanning calorimetry(DSC),and infrared spectroscopy(IR).And the stability of nomegestrol acetate co-crystal was further investigated.Results:The structural characterization showed that the normegestrel acetate-vanillic acid co-crystal had been prepared successfully,and the stability studies showed that the normegestrel acetate-vanillic acid co-crystal had better stability.Conclusion:The co-crystal of the normegestrel acetate-vanillic acid has better physical stability,and which is the potential medicinal solid form.

关 键 词：诺美孕酮醋酸酯 共晶 稳定性 

分 类 号：R914[医药卫生—药物化学]