子宫肌瘤患者血清Ang-2、HE4和ICF-1表达预测宫腔镜术后复发效果  

Values of the expression levels of serum angiopoietin-2,human epididymal secretory protein4,and insulin-like growth factor-1 of women with uterine fibroids for predicting their hysteroscopic postoperative recurrence of uterine fibroids

作　　者：王小丽 闵春明 闫益芬 WANG Xiaoli;MIN Chunming;YAN Yifen(The Affiliated People's Hospital of Hubei University of Medicine,Hubei Province,442000)

机构地区：[1]湖北医药学院附属人民医院,442000

出　　处：《中国计划生育学杂志》2023年第9期2247-2250,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨子宫肌瘤患者血清促血管生成素-2(Ang-2)、人附睾分泌蛋白4(HE4)和胰岛素样生长因子-1(ICF-1)表达对宫腔镜术后复发的预测价值。方法:回顾性分析2019年1月-2020年10月本院妇产科接受治疗的126例子宫肌瘤患者为肌瘤组,体检健康妇女100例为对照组,肌瘤组采用宫腔镜手术治疗,术后随访1年,依据临床影像学及病理检查确诊肌瘤复发。比较肌瘤组术前和对照组体检当天血清Ang-2、HE4和ICF-1水平,根据随访结果判定子宫肌瘤复发者和未复发者,比较两类患者血清Ang-2、HE4和ICF-1水平,采用受术者工作特征曲线(ROC)分析Ang-2、HE4和ICF-1表达对宫腔镜术后肌瘤复发的预测价值。结果:血清Ang-2、HE4和ICF-1水平肌瘤组均高于对照组,且肌瘤组术后复发组(14例)高于未复发组(112例)(均P<0.05);血清Ang-2、HE4和ICF-1水平预测术后肌瘤复发的敏感度分别为83.8%、71.6%、51.4%,特异度分别为78.8%、75.0%、73.1%,3项联合检测预测术后复发的曲线下面积0.906,敏感度85.1%、特异度86.5%。结论:子宫肌瘤患者血清Ang-2、HE4和ICF-1水平异常表达,联合检测血清Ang-2、HE4和ICF-1水平对预测子宫肌瘤术后复发有较高价值。Objective:To investigate the values of the expression levels of serum angiopoietin-2(Ang-2),human epididymal secretory protein 4(HE4),and insulin-like growth factor-1(IGF-1)of women with uterine fibroids for predicting their hysteroscopic postoperative recurrence of uterine fibroids.Methods:126women with uterine fibroids who had treated with hysteroscopic surgery in hospital from January 2019to October 2020in study group were analyzed retrospectively.100healthy women who had been physical examination during the same period were selected in control group.The levels of the serum Ang-2,HE4,and IGF-1were compared between the women in the study group before surgery and the women in the control group on the day of physical examination.The women in the study group were given postoperative follow-up for 1year,and which were further divided in group A(women with the recurrence of uterine fibroids)and group B(women without the recurrence of uterine fibroids)based on the results of clinical imaging and pathological examination of the women.The levels of serum Ang-2,HE4,and IGF-1of the women were compared between group A and group B.Pearson correlation analysis was used to analyze the correlation between the levels of serum Ang-2,HE4,and IGF-1of the women in the study group and their recurrence of uterine fibroids after surgery.The values of Ang-2,HE4,and IGF-1levels of the women in the study group for predicting their recurrence of uterine fibroids after hysteroscopic surgery were analyzed by operating characteristic curve(ROC).Results:The serum Ang-2,HE4and IGF-1levels of the women in the study group were significantly higher than those of the women in the control group,and which of 14women in group A were significantly higher than those of 112women in group B(all P<0.05).The levels of serum Ang-2,HE4,and IGF-1of the women in the study group were positively correlated with their postoperative recurrence(P<0.05).The sensitivity of the levels of serum Ang-2,HE4,and IGF-1of the women for predicting their postoperative uterine

关 键 词：子宫肌瘤 宫腔镜 促血管生成素-2 HE4人附睾分泌蛋白4 胰岛素样生长因子-1 术后复发 预测 

分 类 号：R737.33[医药卫生—肿瘤]