肺腺癌相关肺栓塞肿瘤基因突变及危险因素分析  

Tumor Gene Mutation And Risk Factors Analysis Of Lung Adenocarcinoma Associated Pulmonary Embolism

作　　者：赖健 李建国[1] 颛孙永勋[1] LAI Jian;LI Jian-guo;ZHUANSUN Yong-xun(Department of Respirology,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou,510120;Department of General Practice,The Second People's Hospital of Huadu,Guangzhou)

机构地区：[1]中山大学孙逸仙纪念医院呼吸与危重症医学科,510120 [2]广东省广州市花都区第二人民医院全科医学科

出　　处：《岭南急诊医学杂志》2023年第4期319-321,339,共4页Lingnan Journal of Emergency Medicine

摘　　要：目的:探讨肺腺癌并发肺栓塞(PE)的危险因素及其与肿瘤基因突变的关系。方法:选取肺腺癌合并PE患者30例,随机抽取性别、年龄、肿瘤分期匹配的肺腺癌不合并PE患者90例患者作为对照。收集患者临床资料及瘤基因检测结果,分析其与PE发生的相关性。结果:PE组D二聚体水平显著高于非PE组(P=0.001),PE组高密度脂蛋白胆固醇水平显著低于非PE组(P=0.006)。PE组抗血管治疗(P=0.018)及靶向治疗(P=0.004)的比例显著高于非PE组。两组患者EGFR、ALK、ROS1、ERBB2、BRAF、MET、RET、KRAS、PIK3CA突变频率差异无统计学意义(P>0.05)。D二聚体升高(OR1.404,95%CI 1.138-1.732,P=0.002)、高血压病史(OR11.176,95%CI1.388-89.971,P=0.023)、抗血管生成治疗(OR19.649,95%CI1.651-233.872,P=0.018)与肺腺癌患者并发PE相关。结论:肺腺癌相关体细胞基因突变与PE的发生无显著关联。D二聚体升高、高血压病史、抗血管生成治疗是肺腺癌患者并发PE的危险因素。Objective:To explore the risk factors oflung adenocarcinoma(LUAD)associated pulmonary embolism(PE)and its relationship with tumor gene mutations.Methods:30 cases with LUAD associated PE were selected and 90 gender,age,tumor staging matched controls of LUAD without PE were random sampled.Collect patientsclinical data and tumor genetic testing results and analyze its correlation with PE.Results:The level of D⁃dimer in PE group was sig⁃nificantly higher than that in non⁃PE group(P=0.001).The level of high⁃density lipoprotein cholesterol in PE group was significantly lower than that in non⁃PE group(P=0.003).The proportion of anti⁃angiogenesis therapy(P=0.018)and tar⁃geted therapy(P=0.004)in the PE group was significantly higher than that in the non⁃PE group.There was no statistical⁃ly significant difference in the frequency of EGFR,ALK,ROS1,ERBB2,BRAF,MET,RET,KRAS,and PIK3CA mutations between the two groups(P>0.05).The increase of D⁃dimer(OR1.404,95%CI 1.138⁃1.732,P=0.002),hy⁃pertension(OR11.176,95%CI1.388-89.971,P=0.023),and anti⁃angiogenesis therapy(OR19.649,95%CI1.651-233.872,P=0.018)were associated with PE in patients with LUAD.Conclusion:Tumor gene mutations were not signif⁃icantly associated with LUAD associated PE.The increase of D⁃dimer,hypertension,and anti⁃angiogenesis therapy were risk factors of LUAD associated PE.

关 键 词：肺癌 肺腺癌 肺栓塞 基因 

分 类 号：R734.2[医药卫生—肿瘤]