缺氧诱导因子1α在肝纤维化发生发展中的研究进展  

Research Progress of HIF-1α in the Development of Hepatic Fibrosis

作　　者：向会耀 王海燕[2] 吴利涛 周鑫 谭青青 向希映[1] 罗春华[1] 李乾元[1] Xiang Huiyao;Wang Haiyan;Wu Litao;Zhou Xin;Tan Qingqing;Xiang Xiying;Luo Chunhua;Li Qianyuan(Department of Clinical Laboratory,Yichang Central People's Hospital,The First College of Clinical Medical Science,China Three Gorges University,Yichang 443003,China;Department of Hematology,Yichang Central People's Hospital,The First College of Clinical Medical Science,China Three Gorges University,Yichang 443003,China;Department of Clinical Laboratory,Yichang Maternal and Child Health Hospital,Yichang 443008,China)

机构地区：[1]三峡大学第一临床医学院[宜昌市中心人民医院]检验科,湖北宜昌443003 [2]三峡大学第一临床医学院[宜昌市中心人民医院]血液内科,湖北宜昌443003 [3]宜昌市妇幼保健院检验科,湖北宜昌443008

出　　处：《巴楚医学》2023年第3期120-123,共4页Bachu Medical Journal

基　　金：湖北省教育厅自然科学研究计划项目(No:D201313087);宜昌市医疗卫生科研基金资助项目(No:A19-301-09)。

摘　　要：早期和急性终末期肝纤维化患者常伴随不同程度肝脏缺血性坏死现象发生。缺氧诱导转录因子1α(HIF-1α)是调节肝窦或肝小叶缺血坏死反应的一种关键性转录因子。在肝纤维化发展致肝坏死的历程中,HIF-1α分子在肝星状细胞激活、增殖、分化及信号转导中扮演着不可替代的重要角色。本文拟就肝星状细胞HIF-1α在肝脏纤维化发生发展中的研究进展进行详细阐述,以期为肝纤维化疾病的进一步研究提供理论参考。Patients of the early and acute end-stage hepatic fibrosis are often accompanied by varying degrees of hepatic ischemic necrosis.Hypoxia-inducible transcription factor-1α(HIF-1α)is a key transcription factor that regulates the hepatic sinusoidal or lobular ischemia necrosis.HIF-1αplays an irreplaceable role in the activation,proliferation,differentiation and signal transduction of hepatic stellate cells in the process of liver fibrosis leading to hepatic necrosis.This review aims to elaborate the research progress of HIF-1αof hepatic stellate cell in the occurrence and development of hepatic fibrosis,in order to provide theoretical reference for further research.

关 键 词：肝纤维化 缺氧诱导因子1Α 基因靶点 信号转导 

分 类 号：R575[医药卫生—消化系统]