Molecular events in the jaw vascular unit:A traditional review of the mechanisms involved in inflammatory jaw bone diseases  

作　　者：Ruyu Wang Haoran Wang Junyu Mu Hua Yuan Yongchu Pang Yuli Wang Yifei Du Feng Han 

机构地区：[1]Department of Oral and Maxillofacial Surgery,the Affiliated Stomatological Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China [2]Jiangsu Province Key Laboratory of Oral Diseases,Nanjing Medical University,Nanjing,Jiangsu 210029,China [3]Jiangsu Province Engineering Research Center of Stomatological Translational Medicine,Nanjing,Jiangsu 210029,China [4]International Joint Laboratory for Drug Target of Critical Illnesses,Key Laboratory of Cardiovascular and Cerebrovascular Medicine,School of Pharmacy,Nanjing Medical University,Nanjing,Jiangsu 211166,China [5]Department of Orthodontics,the Affiliated Stomatological Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China.

出　　处：《The Journal of Biomedical Research》2023年第5期313-325,共13页生物医学研究杂志（英文版）

基　　金：supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions(Grant No.PAPD-2018-87);Jiangsu Province Capability Improvement Project through Science,Technology and Education-Jiangsu Provincial Research Hospital Cultivation Unit(Grant No.YJXYYJSDW4);Jiangsu Provincial Medical Innovation Center(Grant No.CXZX202227).

摘　　要：Inflammatory jaw bone diseases are common in stomatology,including periodontitis,peri-implantitis,medication-related osteonecrosis of the jaw,radiation osteomyelitis of the jaw,age-related osteoporosis,and other specific infections.These diseases may lead to tooth loss and maxillofacial deformities,severely affecting patients'quality of life.Over the years,the reconstruction of jaw bone deficiency caused by inflammatory diseases has emerged as a medical and socioeconomic challenge.Therefore,exploring the pathogenesis of inflammatory diseases associated with jaw bones is crucial for improving prognosis and developing new targeted therapies.Accumulating evidence indicates that the integrated bone formation and dysfunction arise from complex interactions among a network of multiple cell types,including osteoblast-associated cells,immune cells,blood vessels,and lymphatic vessels.However,the role of these different cells in the inflammatory process and the'rules'with which they interact are still not fully understood.Although many investigations have focused on specific pathological processes and molecular events in inflammatory jaw diseases,few articles offer a perspective of integration.Here,we review the changes and mechanisms of various cell types in inflammatory jaw diseases,with the hope of providing insights to drive future research in this field.

关 键 词：inflammatory diseases osteogenesis-related cells immune cells blood vessels lymphatic vessels jaw vascular unit 

分 类 号：R782[医药卫生—口腔医学]