空腹血糖与piR-30715的交互作用对胃癌术后患者预后的影响  

The Influence of the Interaction between Fasting Blood Glucose and piR-30715 on the Prognosis of Gastric Cancer Patients after Surgery

作　　者：林云钗[1,2] 胡丹[3] 林贤东[3] 彭峰[1,2] LIN Yunchai;HU Dan;LIN Xiandong;PENG Feng(Department of Cardiology,the First Affiliated Hospital of Fujian Medical University,Fuzhou 350000,China;Department of Cardiology,National Regional Medical Center,Binhai Campus of the First Affiliated Hospital,Fujian Medical University,Fuzhou 350212,China;Department of Pathology of Fujian Cancer Hospital Affiliated to Fujian Medical University,Fuzhou 350014,China)

机构地区：[1]福建医科大学附属第一医院,心血管内科,福州350000 [2]福建医科大学附属第一医院滨海院区国家区域医疗中心,心血管内科,福州350212 [3]福建医科大学附属福建省肿瘤医院,病理科,福州350014

出　　处：《中国细胞生物学学报》2023年第8期1173-1181,共9页Chinese Journal of Cell Biology

基　　金：福建省科技计划对外合作项目(批准号:2021I0013);福建省自然科学基金(批准号:2022J01686);福建省科技创新联合基金(批准号:2021Y9144);国家自然科学基金(批准号:81970370);福建省科技创新联合基金(批准号:2021Y9121)资助的课题。

摘　　要：该文旨在探讨空腹血糖和PIWI蛋白相互作用RNA 30715(PIWI interacting RNA-30715,piR-30715)与胃癌预后的关系。于2014年9月~2016年10月,收集福建省肿瘤医院收治的66例接受根治性胃切除术的胃癌患者。分析癌组织及癌旁组织的piR-30715、PIWI样蛋白4(PIWI-like 4,PIWIL4)表达情况;Kaplan-Meier生存曲线分析空腹血糖、piR-30715、PIWIL4与胃癌术后患者预后的关系;COX回归分析空腹血糖升高和piR-30715对胃癌术后患者预后的交互作用。与癌旁组织比,癌组织的piR-30715、PIWIL4阳性表达例数明显增高(P<0.05)。随访截止到2020年12月31日,66例胃癌随访时间为1.25~75.73个月,中位随访时间为57.05个月。66例胃癌患者中,25例(37.88%)死亡,41例(62.12%)存活。单因素分析显示,空腹血糖(OR=1.965,P<0.001)、piR-30715(OR=2.002,P=0.016)、PIWIL4阳性(OR=2.683,P=0.018)、分期(tumor node metastasis,TNM)(OR=5.755,P=0.018)、远处转移(OR=4.693,P=0.003)及淋巴结转移(OR=3.654,P=0.036)均与胃癌患者预后相关。COX分析显示,空腹血糖升高和piR-30715高表达是胃癌预后的独立危险因素(P<0.05)。生存分析显示,高空腹血糖组和piR-30715高表达组的胃癌患者的总体生存率较低(P<0.05)。空腹血糖和piR-30715对胃癌预后存在相乘交互作用(P相乘=0.003),无相加交互作用(P>0.05)。空腹血糖升高和piR-30715高表达是胃癌预后的独立危险因素,空腹血糖升高与piR-30715高表达对胃癌预后有相乘交互作用。The paper aimed to study the effect of fasting blood glucose levels and piR-30715(PIWI interacting RNA 30715)expression on the prognosis of gastric cancer.A total of 66 patients with gastric cancer underwent radical gastrectomy were enrolled from September 2014 to October 2016.The expression of piR-30715 and PIWIL4(PIWI-like 4)in cancer tissues and adjacent tissues was analyzed.The Kaplan-Meier survival curve was used to analyze the relationship between fasting blood glucose,piR-30715,PIWIL4 and postoperative prognosis of gastric cancer patients.The COX regression was used to study the interaction between fasting blood glucose,piR30715 and the prognosis of postoperative gastric cancer patients.Compared with adjacent tissues,the expression of piR-30715 and PIWIL4 in cancer tissue was significantly increased(P<0.05).As of December 31,2020,66 cases of gastric cancer were followed up for 1.25 to 75.73 months,with a median follow-up time of 57.05 months.Among 66 gastric cancer patients,25(37.88%)died and 41(62.12%)survived.The univariate analysis showed that fasting blood glucose(OR=1.965,P<0.001),piR-30715(OR=2.002,P=0.016),PIWIL4 positive(OR=2.683,P=0.018),TNM(tumor node metastasis)staging(OR=5.755,P=0.018),distant metastasis(OR=4.693,P=0.003)and lymph node metastasis(OR=3.654,P=0.036)were all associated with the prognosis of gastric cancer patients.The COX analysis showed that elevated fasting blood glucose and higher expression of piR-30715 were independent risk factors for the prognosis of gastric cancer(P<0.05).The survival analysis showed that the overall survival rate of gastric cancer patients in the higer fasting blood glucose group and higher expression of piR-30715 group was lower(P<0.05).There is a multiplicative interaction between fasting blood glucose and piR-30715 on the prognosis of gastric cancer(Pmultiplicative=0.003),but no additive interaction(P>0.05).Higher fasting blood glucose and higher expression of piR30715 are independent risk factors for the prognosis of gastric cancer,and there is a mult

关 键 词：胃癌 空腹血糖 piRNA-30715 PIWI样蛋白4 预后 交互作用 

分 类 号：R735.2[医药卫生—肿瘤]