帕金森病患者胃肠功能障碍特点及其风险因素分析  

Characteristics of gastrointestinal dysfunction and risk factors in patients with Parkinson's disease

作　　者：李玺琳[1] 章邱东[1] Li Xilin;Zhang Qiudong(Department of Geriatrics,Fuyang People's Hospital,Fuyang 236000,China)

机构地区：[1]阜阳市人民医院老年医学科,安徽省236000

出　　处：《中华消化病与影像杂志（电子版）》2023年第3期145-149,共5页Chinese Journal of Digestion and Medical Imageology(Electronic Edition)

摘　　要：目的探讨帕金森病(PD)患者胃肠功能障碍的特点,分析相关风险因素,为PD诊疗提供新思路。方法选取2019年1月至2022年10月阜阳市人民医院收治的208例PD患者作为PD组,以同期体检者208例为对照组,评估PD患者运动症状情况(H-Y量表和UPDRS量表)、胃肠消化系统相关症状类型及发生率;比较两组研究对象实验室指标的差异,包括白细胞计数、中性粒细胞计数、淋巴细胞计数、血小板计数、中性粒细胞/淋巴细胞比(NLR)、红细胞分布宽度(RDW)、平均血小板体积(MPV)、血小板分布宽度(PDW)、同型半胱氨酸(HCY)、血尿酸(UA)、胱抑素C(CysC)和炎性指标包括白细胞介素(IL)-2、IL-6和肿瘤坏死因子-α(TNF-α)等实验室指标的差异;通过Logistic多因素回归分析,探究各指标与PD患者胃肠功能障碍的相关性。结果PD患者常见的胃肠消化系统相关症状为便秘(56.7%)、口干(40.9%)、吞咽困难(33.2%)和早期饱腹感(23.6%),且其发生率显著高于对照组(P<0.05);PD组患者HCY、UA、CysC、IL-2、IL-6和TNF-α显著高于对照组(P<0.05);Logistic回归分析显示,H-Y量表评分、UPDRS量表评分、HCY、CysC和IL-6是影响PD患者便秘症状的独立风险因素;而HCY、CysC和IL-6也是影响PD患者口干、吞咽困难和早期饱腹感的独立风险因素。结论便秘、口干、吞咽困难和早期饱腹感是PD患者常见的胃肠功能障碍类型,运动障碍、HCY、CysC和IL-6是其主要的风险因素。Objective To explore the characteristics of gastrointestinal dysfunction in patients with Parkinson's disease(PD),analyze relevant risk factors,and provide new ideas for the diagnosis and treatment of PD.Methods A total of 208 patients with PD admitted to Fuyang People's Hospital from January 2019 to October 2022 were selected as the PD group,and 208 patients who underwent physical examination during the same time were selected as the control group.The exercise symptoms of PD patients(H-Y scale and UPDRS scale),the types and incidence of gastrointestinal digestive system related symptoms were evaluated.The differences of laboratory indicators between the two groups were compared,including white blood cell count,neutrophil count,lymphocyte count,platelet count,neutrophil/lymphocyte ratio(NLR),red blood cell distribution width(RDW),mean platelet volume(MPV),platelet distribution width(PDW),homocysteine(HCY),blood uric acid(UA),cystatin C(CysC),and inflammatory markers such as interleukin(IL)-2,IL-6 and tumor necrosis factor-α(TNF-α).Through multivariate logistic regression analysis,the correlations between various indicators and gastrointestinal dysfunction in PD patients were investigated.Results The common gastrointestinal symptoms of PD patients were constipation(56.7%),dry mouth(40.9%),dysphagia(33.2%)and early satiety(23.6%),and the incidences of the PD group were significantly higher than those of the control group(P<0.05).HCY,UA,CysC,IL-2,IL-6 and TNF-αin the PD group were significantly higher than those in the control group(P<0.05).Logistic regression analysis showed that the score of H-Y scale,the score of UPDRS scale,HCY,CysC and IL-6 were independent risk factors affecting constipation symptom of PD patients.HCY,CysC and IL-6 were also independent risk factors affecting dry mouth,dysphagia and early satiety of PD patients.Conclusion Constipation,dry mouth,dysphagia and early satiety are the common types of gastrointestinal dysfunction in PD patients.Movement disorders,HCY,CysC,and IL-6 are the main ri

关 键 词：帕金森病 胃肠功能障碍 风险因素 

分 类 号：R742.5[医药卫生—神经病学与精神病学]