新精神活性物质分析所涉生物检材类型及应用  

Types and application of biological materials involved in the analysis of new psychoactive substances

作　　者：汤以绫 许琳灏 刘伟 向平 徐莉莉 严慧 TANG Yi-ling;XU Lin-hao;LIU Wei;XIANG Ping;XU Li-li;YAN Hui(Department of Forensic Toxicology,Academy of Forensic Science,Shanghai Key Laboratory of Forensic Medicine,Shanghai 200063,China;School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China)

机构地区：[1]司法鉴定科学研究院,上海市法医学重点实验室,上海市司法鉴定专业技术服务平台司法部司法鉴定重点实验室,上海200063 [2]中国药科大学药学院,南京210009

出　　处：《药物分析杂志》2023年第8期1271-1276,共6页Chinese Journal of Pharmaceutical Analysis

基　　金：国家重点研发计划(2022YFC3302003);中央公益课题(GY2022G-2);上海市法医学重点实验室资助项目(21DZ2270800);司法部司法鉴定重点实验室资助项目;上海市司法鉴定专业技术服务平台资助项目(19DZ2292700)。

摘　　要：新精神活性物质(new psychoactive substances,NPS)是指没有被国际禁毒公约管制,但存在滥用并会对公众健康带来威胁的物质。生物检材中NPS常用免疫法进行快速筛选测试,气相色谱-质谱联用或液相色谱-质谱联用分析技术进行确证分析。目前常规的生物检材有血液、尿液、唾液、玻璃体液、毛发、脏器等,也有研究表明从胎粪、干血斑、干尿斑和干唾液斑中同样能检出NPS成分,关于生物检材的选取也在向着更加便于获取和保存的方向发展。本文综述了不同生物检材的优缺点以及其在NPS分析中的应用,以期为法医和临床毒物分析领域生物检材的选择提供一定的参考。New psychoactive substances(NPS)are substances not controlled by international drug conventions,but exist for abusing and may pose a threat to public health.NPS in biological materials are normally quickly screened by immunoassay,and confirmed by gas chromatography-mass spectrometry or liquid chromatography-mass spectrometry.Currently,biological materials include blood,urine,saliva,vitreous humor,hair,viscera and so on.It has been shown that NPS components can also be detected in meconium,dried blood,urine and saliva spots.The selection of biological samples is evolving towards easy access and preservation.In order to pro⁃vide references for the selection of suitable biological materials,this paper reviews the advantages and disadvanta⁃ges of different biological samples and their applications in NPS analysis.

关 键 词：新精神活性物质 生物检材 毒物分析 气相色谱-质谱联用技术 液相色谱-质谱联用技术 

分 类 号：R917[医药卫生—药物分析学]