2-噻吩甲酰三氟丙酮参与的Biginelli反应  

Biginelli Reaction Using 2-Thenoyltriflouroacetone

作　　者：李公春[1] 牛玉娇 孙娜 吕春杰 Li Gongchun;Niu Yujiao;Sun Na;Lyu Chunjie(School of Food and Pharmacy,Xuchang University,Xuchang 461000,China;Hangzhou Dingfang Technology Co.,Ltd.,Hangzhou 310000,China)

机构地区：[1]许昌学院食品与药学院,河南许昌461000 [2]杭州定方科技有限公司,浙江杭州310000

出　　处：《山东化工》2023年第15期63-64,69,共3页Shandong Chemical Industry

摘　　要：采用Biginelli反应,在氨基磺酸催化下,无水乙醇为溶剂,以2-噻吩甲酰三氟丙酮、芳香醛和脲作原料,合成了一系列5-(2-噻吩甲酰)-6-羟基-6-三氟甲基-3,4,5,6-四氢嘧啶-2-酮衍生物,产率可达82%~98%。A series of 5-(2-thienylcarbonyl)-6-trifluoromethyl-3,4,5,6-tetrahydropyrimidin-2(1H)-one derivatives was synthesized by Biginelli condensation reaction with 2-thenoyltriflouroacetone,aromatic aldehydes and urea as raw materials,in the place of sulfamicacid as catalyst and ethanol as solvent,the yield can gain 82%~98%.

关 键 词：BIGINELLI反应 3 4 5 6-四氢嘧啶-2-酮 三氟甲基 合成 

分 类 号：TQ224.7[化学工程—有机化工] O622.4[理学—有机化学]