Association between alcohol-associated cirrhosis and inpatient complications among COVID-19 patients:A propensity-matched analysis from the United  

作　　者：Faisal Inayat Hassam Ali Pratik Patel Rubaid Dhillon Arslan Afzal Attiq Ur Rehman Muhammad Sohaib Afzal Laraib Zulfiqar Gul Nawaz Muhammad Hassan Naeem Goraya Subanandhini Subramanium Saurabh Agrawal Sanjaya K Satapathy 

机构地区：[1]Department of Internal Medicine,Allama Iqbal Medical College,Lahore 54550,Punjab,Pakistan [2]Department of Internal Medicine,East Carolina University Brody School of Medicine,Greenville,NC 27834,United States [3]Department of Gastroenterology,Mather Hospital and Zucker School of Medicine at Hofstra University,Port Jefferson,NY 11777,United States [4]Department of Gastroenterology,Cleveland Clinic Foundation,Cleveland,OH 44195,United States [5]Department of Hepatology,Mercy Medical Center,Baltimore,MD 21202,United States [6]Department of Internal Medicine,Louisiana State University Health,Shreveport,LA 71103,United States [7]Department of Internal Medicine,Quaid-e-Azam Medical College,Bahawalpur 63100,Punjab,Pakistan [8]Department of Hepatology,Tampa General Medical Group and University of South Florida,Tampa,FL 33606,United States [9]Department of Hepatology,North Shore University Hospital and Zucker School of Medicine at Hofstra University,Manhasset,NY 11030,United States

出　　处：《World Journal of Virology》2023年第4期221-232,共12页世界病毒学杂志

摘　　要：BACKGROUND Alcohol-associated cirrhosis(AC)contributes to significant liver-related mortality in the United States.It is known to cause immune dysfunction and coagulation abnormalities.Patients with comorbid conditions like AC are at risk of worse clinical outcomes from coronavirus disease 2019(COVID-19).The specific association between AC and COVID-19 mortality remains inconclusive,given the lack of robust clinical evi-dence from prior studies.AIM To study the predictors of mortality and the outcomes of AC in patients hospitalized with COVID-19 in the United States.METHODS We conducted a retrospective cohort study using the National Inpatient Sample(NIS)database 2020.Patients were identified with primary COVID-19 hospitalizations based on an underlying diagnosis of AC.A matched comparison cohort of COVID-19 patients without AC was identified after 1:N propensity score matching based on baseline sociodemographic characteristics and Elixhauser comorbidities.Primary outcomes included median length of stay,median inpatient charges,and in-hospital mortality.Secondary outcomes included a prevalence of systemic complications.RESULTS A total of 1325 COVID-19 patients with AC were matched to 1135 patients without AC.There was no difference in median length of stay and hospital charges in COVID-19 patients with AC compared to non-AC(P>0.05).There was an increased prevalence of septic shock(5.7%vs 4.1%),ventricular fibrillation/ventricular flutter(0.4%vs 0%),atrial fibrillation(13.2%vs 8.8%),atrial flutter(8.7%vs 4.4%),first-degree atrioventricular nodal block(0.8%vs 0%),upper extremity venous thromboembolism(1.5%vs 0%),and variceal bleeding(3.8%vs 0%)in the AC cohort compared to the non-AC cohort(P<0.05).There was no difference in inpatient mortality in COVID-19 patients with non-AC compared to AC,with an odds ratio of 0.97(95%confidence interval:0.78-1.22,P=0.85).Predictors of mortality included advanced age,cardiac arrhythmias,coagulopathy,protein-calorie malnutrition,fluid and electrolyte disorders,septic shock,and upp

关 键 词：Alcoholic cirrhosis COVID-19 Chronic liver disease Mortality predictors Inpatient complications 

分 类 号：R57[医药卫生—消化系统]