Advances in drug resistance of triple negative breast cancer caused by pregnane X receptor  

作　　者：Zhou-Zhou Rao Zhong-Wen Tang Jie Wen 

机构地区：[1]Department of Physiology,Hunan Normal University School of Medicine,Changsha 410003,Hunan Province,China [2]Department of Pediatric Orthopedics,Hunan Provincial People’s Hospital,the First Affiliated Hospital of Hunan Normal University,Changsha 410013,Hunan Province,China

出　　处：《World Journal of Clinical Oncology》2023年第9期335-342,共8页世界临床肿瘤学杂志（英文版）

基　　金：Supported by Science project of Hunan Provincial Health Commission,No.B202304089304.

摘　　要：Breast cancer is the most common malignancy in women worldwide.Triplenegative breast cancer(TNBC),refers breast cancer negative for estrogen receptor,progesterone receptor and human epidermal growth factor receptor 2,characterized by high drug resistance,high metastasis and high recurrence,treatment of which is a difficult problem in the clinical treatment of breast cancer.In order to better treat TNBC clinically,it is a very urgent task to explore the mechanism of TNBC resistance in basic breast cancer research.Pregnane X receptor(PXR)is a nuclear receptor whose main biological function is to participate in the metabolism,transport and clearance of allobiological agents in PXR.PXR plays an important role in drug metabolism and clearance,and PXR is highly expressed in tumor tissues of TNBC patients,which is related to the prognosis of breast cancer patients.This reviews synthesized the important role of PXR in the process of high drug resistance to TNBC chemotherapeutic drugs and related research progress.

关 键 词：Triple-negative breast cancer Pregnane X receptor Drug resistance Cytochrome P450 Uridinediphosphate glucuronyl transferases Glutathione transferases ATP-binding cassette transporter 

分 类 号：R737.9[医药卫生—肿瘤]