Recurrence of unilateral angioedema of the tongue:A case report  

作　　者：Yuki Matsuhisa Tsuneaki Kenzaka Hironori Shimizu Hideo Hirose Tadao Gotoh 

机构地区：[1]Department of General Medicine,Center for Community Medicine in North-Western Gifu Prefecture National Health Insurance Shirotori Hospital,Gujo 501-5122,Japan [2]Department of Pediatrics,Center for Community Medicine in North-Western Gifu Prefecture National Health Insurance Shirotori Hospital,Gujo 501-5122,Japan [3]Department of Internal Medicine,Hyogo Prefectural Tamba Medical Center,Tamba 669-3495,Japan [4]Division of Community Medicine and Career Development,Kobe University Graduate School of Medicine,Kobe 652-0032,Japan

出　　处：《World Journal of Clinical Cases》2023年第27期6603-6612,共10页世界临床病例杂志

摘　　要：BACKGROUND Angioedema is a disorder characterized by edema of the face,lips,tongue,and extremities due to increased vascular permeability.Angioedema of the tongue usually occurs bilaterally,and the incidence of unilateral angioedema of the tongue is rare.This study reports a rare case of unilateral angioedema of the tongue with no identifiable cause and repeated recurrence even after discontinuation of an angiotensin-converting enzyme inhibitor.CASE SUMMARY The patient was a 65-year-old woman with pre-existing hypertension and hyperlipidemia and had been receiving 20 mg/d of lisinopril.She was diagnosed with angioedema due to unilateral swelling of the tongue.No airway obstruction was observed,and the symptoms improved following the administration of 0.3 mg of epinephrine intramuscularly and 125 mg of methylprednisolone intravenously.Although lisinopril was discontinued,unilateral angioedema of the tongue continued to recur every 2-5 mo,with the symptoms improving following the administration of prednisolone and an antihistamine.Daily oral administration of 500 mg of tranexamic acid after dinner prevented the recurrence of angioedema.CONCLUSION Careful monitoring and identification of the underlying mechanism play a crucial role in the treatment of angioedema.

关 键 词：ANGIOEDEMA TONGUE UNILATERAL BRADYKININ Tranexamic acid Case report 

分 类 号：R969[医药卫生—药理学]